Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
about
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsThe B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85Positive and negative regulation of T-cell activation through kinases and phosphatasesVav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activationAssociation of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alphaShb links SLP-76 and Vav with the CD3 complex in Jurkat T cellsHematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondA leucine zipper in the N terminus confers membrane association to SLP-65Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytesThe role of Gads in hematopoietic cell signalling.MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling.Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor.Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.Differential role of SLP-76 domains in T cell development and functionThe transmembrane adapter LAT plays a central role in immune receptor signalling.BLNK mediates Syk-dependent Btk activation.Adapters in lymphocyte signalingSignalling scaffolds and adaptors in T-cell immunity.Multitasking of Ig-alpha and Ig-beta to regulate B cell antigen receptor function.Regulation of phospholipase C-gamma2 and phosphoinositide 3-kinase pathways by adaptor proteins in B lymphocytes.Regulation of B-cell signal transduction by adaptor proteins.Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cellsItk: the rheostat of the T cell response.The role of Tec family kinases in T cell development and function.Transmembrane adapters: attractants for cytoplasmic effectors.Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development.Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.Transmembrane adaptor proteins in the high-affinity IgE receptor signalingHigh resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion.Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.Mast cell chemotaxis - chemoattractants and signaling pathways.Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.Identification of the minimal tyrosine residues required for linker for activation of T cell function.
P2860
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P2860
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@ast
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@en
type
label
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@ast
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@en
prefLabel
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@ast
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@en
P2093
P2860
P356
P1476
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
@en
P2093
P2860
P304
P356
10.1084/JEM.192.6.847
P407
P577
2000-09-01T00:00:00Z