Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
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Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypesHIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexesNegative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivityMechanism for down-regulation of CD28 by Nef.Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machineryRecognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexesSERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefHIV-1 Nef promotes infection by excluding SERINC5 from virion incorporationStructure--function relationships in HIV-1 Nef.Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsHuman immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells.Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptinsLeucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexesHIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elementsExosomes are unlikely involved in intercellular Nef transferConformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyStructural basis of evasion of cellular adaptive immunity by HIV-1 NefHow HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibodyMolecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefStructure, dynamics, and Hck interaction of full-length HIV-1 Nef.The HIV-1 Nef protein as a target for antiretroviral therapy.Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients.Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.Analysis of expressed sequence tags from Maize mosaic rhabdovirus-infected gut tissues of Peregrinus maidis reveals the presence of key components of insect innate immunity.Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infectionHIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors.Interactions of HIV-1 with antigen-presenting cells.Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulationSequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivityHuman immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.Ineffectual targeting of HIV-1 Nef by cytotoxic T lymphocytes in acute infection results in no functional impairment or viremia reduction.Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.
P2860
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P2860
Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@ast
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@en
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@nl
type
label
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@ast
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@en
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@nl
prefLabel
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@ast
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@en
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@nl
P2093
P2860
P356
P1476
Interaction of HIV-1 Nef with ...... and optimal viral infectivity
@en
P2093
J C Guatelli
M W Pandori
P2860
P304
P356
10.1073/PNAS.95.19.11229
P407
P577
1998-09-15T00:00:00Z