Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef
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HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via NefHow HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibodyHigh-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domainExpression, purification and preliminary crystallographic studies of the C-terminal SH3 domain of human Tks4.A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction.Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functionsIntracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cellsTat-induced histopathological alterations mediate hippocampus-associated behavioural impairments in rats.The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets.Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target?Viral proteins and Src family kinases: Mechanisms of pathogenicity from a "liaison dangereuse".HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.Non-active site mutations disturb the loop dynamics, dimerization, viral budding and egress of VP40 of the Ebola virus.Dynamic features of apo and bound HIV-Nef protein reveal the anti-HIV dimerization inhibition mechanism.Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef functionA single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.
P2860
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P2860
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef
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2011 nî lūn-bûn
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2011 թուականին հրատարակուած գիտական յօդուած
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2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
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Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@en
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
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type
label
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@ast
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@en
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@nl
prefLabel
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@ast
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@en
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@nl
P2093
P2860
P50
P1433
P1476
Molecular design, functional c ...... HIV-1 pathogenicity factor Nef
@en
P2093
Antje Schulte
Sebastian Breuer
Simone I Schievink
P2860
P304
P356
10.1371/JOURNAL.PONE.0020033
P407
P577
2011-05-20T00:00:00Z