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Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesisThe catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshotsThe paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerusTwo sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerusCrystal structure of carbapenem synthase (CarC)Crystal structure of carbapenam synthetase (CarA)Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathwayConvergent biosynthetic pathways to β-lactam antibioticsThe att locus of Rhodococcus fascians strain D188 is essential for full virulence on tobacco through the production of an autoregulatory compoundStructural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesisGenes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerusEnzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerusExpansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus.A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetaseThe enzymes of β-lactam biosynthesis.ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.Asparagine synthetase chemotherapy.β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster.The evolution of gene collectives: How natural selection drives chemical innovation.Genes Involved in the Production of Antimetabolite Toxins by Pseudomonas syringae Pathovars.Biosynthesis of clavam metabolites.Origins of the β-lactam rings in natural products.Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement.Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines.Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase.A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetaseA new class of glutamate dehydrogenases (GDH). Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus.ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping.Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
beta-Lactam synthetase: a new biosynthetic enzyme
@ast
beta-Lactam synthetase: a new biosynthetic enzyme
@en
beta-Lactam synthetase: a new biosynthetic enzyme
@nl
type
label
beta-Lactam synthetase: a new biosynthetic enzyme
@ast
beta-Lactam synthetase: a new biosynthetic enzyme
@en
beta-Lactam synthetase: a new biosynthetic enzyme
@nl
prefLabel
beta-Lactam synthetase: a new biosynthetic enzyme
@ast
beta-Lactam synthetase: a new biosynthetic enzyme
@en
beta-Lactam synthetase: a new biosynthetic enzyme
@nl
P2093
P2860
P356
P1476
beta-Lactam synthetase: a new biosynthetic enzyme
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.16.9082
P407
P577
1998-08-04T00:00:00Z