Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2 - Wikidata - awgldk - TriplyDB

Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2

Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2

http://www.wikidata.org/entity/Q24796810

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Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics Is the Brain a Quantum Computer?Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.A propofol binding site on mammalian GABAA receptors identified by photolabeling Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.Clinical and molecular pharmacology of etomidate.An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors.Molecular and neuronal substrates for general anaesthetics.Novel positive allosteric modulators of GABAA receptors with anesthetic activity.Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation GABAA-R α4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability.Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors.Potentiating effect of glabridin from Glycyrrhiza glabra on GABAA receptors.Structural basis of neurosteroid anesthetic action on GABA receptors

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Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2

http://www.wikidata.org/entity/Q24796810

description

2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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BMC Pharmacology

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Mutational analysis of molecul ...... tor subtype, alpha1beta2gamma2

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Karin Krähenbühl

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Roberta Siegwart

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Sachar Lambert

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Uwe Rudolph

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P2860

General anaesthetic actions on ligand-gated ion channels

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

Anesthetics and ion channels: molecular models and sites of action.

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.

Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations.

Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors.

Which GABAA-receptor subtypes really occur in the brain?

gamma-Aminobutyric acid gating of Cl- channels in recombinant GABAA receptors.

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scholarly article

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1478606

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10.1186/1471-2210-3-13

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1

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3

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1047036801

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14613517

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280653

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