Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.
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Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsCorrection for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA ReceptorsPhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacologyMultiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sitesMultiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.Assessment of direct gating and allosteric modulatory effects of meprobamate in recombinant GABA(A) receptors.A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptorsDiscovery of a novel general anesthetic chemotype using high-throughput screening.Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspectivePhotoaffinity labeling in target- and binding-site identificationEtomidate uniquely modulates the desensitization of recombinant α1β3δ GABA(A) receptors.The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries.Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors.Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptorsγ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.Novel positive allosteric modulators of GABAA receptors with anesthetic activity.Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 ReceptorsIdentification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptorsNeonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons.Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.Mechanisms revealed through general anesthetic photolabeling.Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling.Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?Photoaffinity labeling the propofol binding site in GLIC.
P2860
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P2860
Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Specificity of intersubunit ge ...... acid type A (GABAA) receptor.
@ast
Specificity of intersubunit ge ...... acid type A (GABAA) receptor.
@en
Specificity of intersubunit ge ...... 3γ2 γ-aminobutyric acid type A
@nl
type
label
Specificity of intersubunit ge ...... acid type A (GABAA) receptor.
@ast
Specificity of intersubunit ge ...... acid type A (GABAA) receptor.
@en
Specificity of intersubunit ge ...... 3γ2 γ-aminobutyric acid type A
@nl
prefLabel
Specificity of intersubunit ge ...... acid type A (GABAA) receptor.
@ast
Specificity of intersubunit ge ...... acid type A (GABAA) receptor.
@en
Specificity of intersubunit ge ...... 3γ2 γ-aminobutyric acid type A
@nl
P2093
P2860
P356
P1476
Specificity of intersubunit ge ...... c acid type A (GABAA) receptor
@en
P2093
David C Chiara
Jonathan B Cohen
Karol S Bruzik
Keith W Miller
Pavel Y Savechenkov
Xiaojuan Zhou
P2860
P304
19343-19357
P356
10.1074/JBC.M113.479725
P407
P577
2013-05-15T00:00:00Z