AMP-activated protein kinase: a target for drugs both ancient and modern - Wikidata - awgldk - TriplyDB

AMP-activated protein kinase: a target for drugs both ancient and modern

AMP-activated protein kinase: a target for drugs both ancient and modern

http://www.wikidata.org/entity/Q26864424

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Adenosine monophosphate-activated protein kinase in diabetic nephropathy Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection Inflammation and intracellular metabolism: new targets in OA Autophagy signal transduction by ATG proteins: from hierarchies to networks Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?New avenues for regulation of lipid metabolism by thyroid hormones and analogs AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes Structural basis of AMPK regulation by small molecule activators Evidence of cancer-promoting roles for AMPK and related kinases Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis Adiponectin enhances intercellular adhesion molecule-1 expression and promotes monocyte adhesion in human synovial fibroblasts Lipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinase Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.Minireview: Obesity and breast cancer: a tale of inflammation and dysregulated metabolism Effect of different γ-subunit isoforms on the regulation of AMPK The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism.The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells.Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK Ras transformation uncouples the kinesin-coordinated cellular nutrient response Regulation of glucose-dependent gene expression by the RNA helicase Dbp2 in Saccharomyces cerevisiae.Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation.Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases MLK3 phophorylates AMPK independently of LKB1.Proteomic database mining opens up avenues utilizing extracellular protein phosphorylation for novel therapeutic applications.Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells.Targeting AMPK for cancer prevention and treatment.Metformin potentiates rapamycin and cisplatin in gastric cancer in mice.GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation Structural basis of AMPK regulation by adenine nucleotides and glycogen.Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.The multifaceted role of mTORC1 in the control of lipid metabolism

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AMP-activated protein kinase: a target for drugs both ancient and modern

http://www.wikidata.org/entity/Q26864424

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2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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AMP-activated protein kinase: a target for drugs both ancient and modern

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J.CHEMBIOL.2012.08.019

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Chemistry and Biology

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AMP-activated protein kinase: a target for drugs both ancient and modern

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Fiona A Ross

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Simon A Hawley

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Mechanism by which metformin reduces glucose production in type 2 diabetes

Role of AMP-activated protein kinase in mechanism of metformin action

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

Structural basis for AMP binding to mammalian AMP-activated protein kinase

Structure of mammalian AMPK and its regulation by ADP

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

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1222-1236

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scholarly article

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3060776

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10.1016/J.CHEMBIOL.2012.08.019

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10

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19

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David Grahame Hardie

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2012-10-01T00:00:00Z

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232718290

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23102217

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5722193

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