Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts
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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersK-Cl cotransporters, cell volume homeostasis, and neurological diseaseCurrent view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Modeling glial contributions to seizures and epileptogenesis: cation-chloride cotransporters in Drosophila melanogasterMolecular and evolutionary insights into the structural organization of cation chloride cotransportersA trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport functionThe Concise Guide to PHARMACOLOGY 2013/14: transporters.Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.Homeostasis, the milieu intérieur, and the wisdom of the nephronA novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation.Cation-chloride cotransporters in neuronal development, plasticity and diseaseCritical role of the SPAK protein kinase CCT domain in controlling blood pressureA missense mutation in solute carrier family 12, member 1 (SLC12A1) causes hydrallantois in Japanese Black cattleRegulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophreniaInhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Hypertension: the missing WNKs.Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.A patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1.Physiology and pathophysiology of SLC12A1/2 transporters.Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive ratK-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function.The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.Physiological role of SLC12 family members in the kidney.A genome-wide association study in a large F2-cross of laying hens reveals novel genomic regions associated with feather pecking and aggressive pecking behavior.Chloride co-transporters as possible therapeutic targets for stroke.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.Evolution of the cation chloride cotransporter family: ancient origins, gene losses, and subfunctionalization through duplication.Underdominant KCC3b R31I association with blood sodium concentration in domestic sheep suggests role in oligomer function.Defective SLC12A1 causes Bartter syndrome 1 (BS1)K+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective.The signaling role for chloride in the bidirectional communication between neurons and astrocytes.Differences in molecular mechanisms of K+ clearance in the auditory sensory epithelium of birds and mammals.Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation.Role of Cl- -HCO3- exchanger AE3 in intracellular pH homeostasis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes.
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P2860
Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@ast
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@en
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@nl
type
label
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@ast
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@en
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@nl
prefLabel
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@ast
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@en
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@nl
P2860
P3181
P1476
Physiology of SLC12 transporte ...... lly engineered mouse knockouts
@en
P2093
E. Delpire
K. B. Gagnon
P2860
P304
P3181
P356
10.1152/AJPCELL.00350.2012
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P577
2013-04-15T00:00:00Z