The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. - Wikidata - awgldk - TriplyDB

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

http://www.wikidata.org/entity/Q38230038

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Development and regulation of chloride homeostasis in the central nervous system K-Cl cotransporters, cell volume homeostasis, and neurological disease Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK Molecular and evolutionary insights into the structural organization of cation chloride cotransporters American Society of Nephrology Quiz and Questionnaire 2015: Electrolytes and Acid-Base Disorders.Reactive Neurogenesis and Down-Regulation of the Potassium-Chloride Cotransporter KCC2 in the Cochlear Nuclei after Cochlear Deafferentation.WNK1 kinase balances T cell adhesion versus migration in vivo Cation-chloride cotransporters in neuronal development, plasticity and disease Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line.Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control.Critical role of the SPAK protein kinase CCT domain in controlling blood pressure Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.The Neurobiology of Circadian Rhythms Cell-specific regulation of L-WNK1 by dietary K.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Maintaining K+ balance on the low-Na+, high-K+ diet.STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and Plasticity Ultra-long-term human salt balance studies reveal interrelations between sodium, potassium, and chloride intake and excretion A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence Gordon Syndrome: a continuing story.Going for broke: targeting the human cancer pseudokinome.Dietary potassium and the renal control of salt balance and blood pressure.Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.WNK Kinases in Development and Disease.Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis.WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.Molecular mechanisms underlying active desalination and low water permeability in the esophagus of eels acclimated to seawater.Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity.

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

http://www.wikidata.org/entity/Q38230038

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

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Arjun Khanna

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Kristopher T Kahle

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Thomas Hochdörfer

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Yuze Shang

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Similar effects of all WNK3 variants on SLC12 cotransporters

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

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10.1126/SCISIGNAL.2005365

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334

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