Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease - Wikidata - awgldk - TriplyDB

Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease

Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease

http://www.wikidata.org/entity/Q27302176

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The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity Mitochondrial biology and Parkinson's disease No immune responses by the expression of the yeast Ndi1 protein in rats Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan.Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of Parkinson disorder.Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death.Protective Role of rAAV-NDI1, Serotype 5, in an Acute MPTP Mouse Parkinson's Model.Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.Reduction of infarct size by the therapeutic protein TAT-Ndi1 in vivo Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats.JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.Mitochondrial energetics and therapeutics.Cell-permeable protein therapy for complex I dysfunction Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases.Axon degeneration in Parkinson's disease shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model Mitochondrial respiratory complex I: structure, function and implication in human diseases.AIF, reactive oxygen species, and neurodegeneration: a "complex" problem The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes.Progress and prospects: gene therapy for mitochondrial DNA disease.A phenotypic model recapitulating the neuropathology of Parkinson's disease.Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease.Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.Mitochondrial medicine for neurodegenerative diseases.The approaches for manipulating mitochondrial proteome Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.Oxidative damage to macromolecules in human Parkinson disease and the rotenone model.Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency.Mitochondrial type II NAD(P)H dehydrogenases in fungal cell death Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction.Expression of yeast NDI1 rescues a Drosophila complex I assembly defect.

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Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease

http://www.wikidata.org/entity/Q27302176

description

2008 nî lūn-bûn

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2008年の論文

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Protection by the NDI1 gene ag ...... t model of Parkinson's disease

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Akemi Matsuno-Yagi

http://www.w3.org/2001/XMLSchema#string

Byoung Boo Seo

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Eiko Nakamaru-Ogiso

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J Timothy Greenamyre

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Mathieu Marella

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Takao Yagi

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P2860

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases

Crossroads in GDNF therapy for Parkinson's disease

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe.

Cytotoxic and genotoxic potential of dopamine.

Role of quinones in toxicology.

Mechanism of toxicity in rotenone models of Parkinson's disease.

Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity.

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scholarly article

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10.1371/JOURNAL.PONE.0001433

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1

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5654773

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18197244

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Parkinson's disease

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2175531

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