Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.
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Ubiquitin is phosphorylated by PINK1 to activate parkinLRRK2 transport is regulated by its novel interacting partner Rab32Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionProthrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic SystemCross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseNeuroprotective Transcription Factors in Animal Models of Parkinson DiseaseTurning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's DiseaseAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseasePathologic and therapeutic implications for the cell biology of parkinMitochondrial genome changes and neurodegenerative diseasesNeuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animalsPhysiological characterisation of human iPS-derived dopaminergic neuronsOpa1 is required for proper mitochondrial metabolism in early developmentStructure of parkin reveals mechanisms for ubiquitin ligase activationDysregulation of autophagy and mitochondrial function in Parkinson's diseaseParkinson's disease: animal models and dopaminergic cell vulnerabilityGDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseCholine dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagyMitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes.Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemInteractions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's diseaseGaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imigluceraseMitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicityProgressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's diseaseDopamine-agonist responsive Parkinsonism in a patient with the SANDO syndrome caused by POLG mutation.PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligaseSubcellular expression and neuroprotective effects of SK channels in human dopaminergic neuronsXanthoceraside ameliorates mitochondrial dysfunction contributing to the improvement of learning and memory impairment in mice with intracerebroventricular injection of aβ1-42.VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells.Boronate-based fluorescent probes: imaging hydrogen peroxide in living systems.Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease.Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivoGlycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson diseaseTom70 is essential for PINK1 import into mitochondria
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P2860
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Mitochondrial dysfunction in P ...... thophysiological consequences.
@en
type
label
Mitochondrial dysfunction in P ...... thophysiological consequences.
@en
prefLabel
Mitochondrial dysfunction in P ...... thophysiological consequences.
@en
P2860
P356
P1433
P1476
Mitochondrial dysfunction in P ...... thophysiological consequences.
@en
P2093
Anne Kathrin Lutz
Nicole Exner
P2860
P304
P356
10.1038/EMBOJ.2012.170
P407
P577
2012-06-26T00:00:00Z