HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons
about
Diverse molecular targets for therapeutic strategies in Alzheimer's diseaseThe promise and perils of HDAC inhibitors in neurodegenerationGenetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth DiseaseAcetylation: a new key to unlock tau's role in neurodegenerationThe development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease.Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibitionA selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors--What Some May Have Forgotten or Would Rather Forget?Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability.Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport.Regulation of autophagy and mitophagy by nutrient availability and acetylation.Axonal transport defects in Alzheimer's disease.Histone deacetylase 6 in health and disease.Histone Acetylation Modifiers in the Pathogenesis of Alzheimer's Disease.HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging.A Mitocentric View of Alzheimer's Disease.Soluble N-terminal fragment of mutant Huntingtin protein impairs mitochondrial axonal transport in cultured hippocampal neurons.An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.Discovery of a fluorescent probe with HDAC6 selective inhibition.Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS.Complex neuroprotective and neurotoxic effects of histone deacetylases.Class II HDACs and neuronal regeneration.Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells.Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.
P2860
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P2860
HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@ast
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@en
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@nl
type
label
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@ast
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@en
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@nl
prefLabel
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@ast
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@en
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@nl
P2093
P2860
P1433
P1476
HDAC6 inhibitor blocks amyloid ...... ansport in hippocampal neurons
@en
P2093
Chaeyoung Kim
Eun Sun Jung
Heesun Choi
Inhee Mook-Jung
Noo Li Jeon
Soojung Oh
P2860
P304
P356
10.1371/JOURNAL.PONE.0042983
P407
P577
2012-01-01T00:00:00Z