Corresponding functional dynamics across the Hsp90 Chaperone family: insights from a multiscale analysis of MD simulations
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Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulationsStructural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis MechanismMechanical and assembly units of viral capsids identified via quasi-rigid domain decompositionInvestigating the dynamic aspects of drug-protein recognition through a combination of MD and NMR analyses: implications for the development of protein-protein interaction inhibitorsExploring the Functional Complementation between Grp94 and Hsp90DNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational SimulationsDifferential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.Allosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modelingComputational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL.Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule.Molecular and thermodynamic insights into the conformational transitions of Hsp90.The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular DesignMolecular dynamics simulations of hsp90 with an eye to inhibitor design.Heat-shock protein 90 (Hsp90) as anticancer target for drug discovery: an ample computational perspective.Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells.Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.Exploiting conformational dynamics in drug discovery: design of C-terminal inhibitors of Hsp90 with improved activities.Pharmacological enhancement of α-glucosidase by the allosteric chaperone N-acetylcysteine.Force distribution reveals signal transduction in E. coli Hsp90.A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro.Understanding the role of domain-domain linkers in the spatial orientation of domains in multi-domain proteins.Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc.
P2860
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P2860
Corresponding functional dynamics across the Hsp90 Chaperone family: insights from a multiscale analysis of MD simulations
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Corresponding functional dynam ...... ale analysis of MD simulations
@ast
Corresponding functional dynam ...... ale analysis of MD simulations
@en
Corresponding functional dynam ...... ale analysis of MD simulations
@nl
type
label
Corresponding functional dynam ...... ale analysis of MD simulations
@ast
Corresponding functional dynam ...... ale analysis of MD simulations
@en
Corresponding functional dynam ...... ale analysis of MD simulations
@nl
prefLabel
Corresponding functional dynam ...... ale analysis of MD simulations
@ast
Corresponding functional dynam ...... ale analysis of MD simulations
@en
Corresponding functional dynam ...... ale analysis of MD simulations
@nl
P2860
P50
P3181
P1476
Corresponding functional dynam ...... ale analysis of MD simulations
@en
P2093
Cristian Micheletti
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1002433
P407
P577
2012-01-01T00:00:00Z