Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors - Wikidata - awgldk - TriplyDB

Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

http://www.wikidata.org/entity/Q27480926

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Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance Effects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various Genotypes Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors 1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus 1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.De novo polymerase activity and oligomerization of hepatitis C virus RNA-dependent RNA-polymerases from genotypes 1 to 5 Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor Avoiding therapeutic pitfalls: the rational use of specifically targeted agents against hepatitis C infection.New NS5B polymerase inhibitors for hepatitis C.Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends.Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor.Inhibition of dengue virus polymerase by blocking of the RNA tunnel Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase.Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment.A fluorescence-based high-throughput screen to identify small compound inhibitors of the genotype 3a hepatitis C virus RNA polymerase.Rong's numbers: accelerating progress in HCV therapeutic research.Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway.

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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

http://www.wikidata.org/entity/Q27480926

description

2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Binding-Site Identification an ...... C Virus Polymerase Inhibitors

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Binding-Site Identification an ...... C Virus Polymerase Inhibitors

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Binding-Site Identification an ...... C Virus Polymerase Inhibitors

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P2093

Anne-Stéphanie Rueff

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Carlo W Boutton

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Dominique Surleraux

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Erna Cleiren

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Frederik Pauwels

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Kenneth A Simmen

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Liesbet van der Helm

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Ludo M M Quirynen

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Origène Nyanguile

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Pierre Raboisson

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P2860

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli.

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

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6909-19

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scholarly article

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10.1128/JVI.01543-06

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13

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81

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2007-07-01T00:00:00Z

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6369145

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17459932

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1933266

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