Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme - Wikidata - awgldk - TriplyDB

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

http://www.wikidata.org/entity/Q27477662

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Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor Development of a Novel Dicistronic Reporter-Selectable Hepatitis C Virus Replicon Suitable for High-Throughput Inhibitor Screening Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors In Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase Structure-function relationships among RNA-dependent RNA polymerases Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796 Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase 1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase Analysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation.Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase.De novo polymerase activity and oligomerization of hepatitis C virus RNA-dependent RNA-polymerases from genotypes 1 to 5 Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients.Recent developments in target identification against hepatitis C virus.Challenges and successes in developing new therapies for hepatitis C.Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase.Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges.Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends.Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication.Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.Mutational evidence for a structural model of the Lassa virus RNA polymerase domain and identification of two residues, Gly1394 and Asp1395, that are critical for transcription but not replication of the genome Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.Natural variation in drug susceptibility to HCV polymerase inhibitors in treatment-naïve HCV patient isolates.QSAR study of HCV NS5B polymerase inhibitors using the genetic algorithm-multiple linear regression (GA-MLR).

P2860

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P2860

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

http://www.wikidata.org/entity/Q27477662

description

2003 nî lūn-bûn

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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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JVI.77.13.7575-7581.2003

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Journal of Virology

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Crystallographic Identificatio ...... rus NS5B RNA Polymerase Enzyme

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P2093

Anne Ekker

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Hans E Parge

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Hilary Wriggers

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James A Thomson

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Jingjin Gao

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Liann Wang

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Michael J Hickey

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Robert A Love

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Shella A Fuhrman

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Wade Diehl

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P2860

Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli.

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase

The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment.

Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.

A mechanism for initiating RNA-dependent RNA polymerization

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7575-81

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scholarly article

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10.1128/JVI.77.13.7575-7581.2003

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13

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77

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Peter S Dragovich

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2003-07-01T00:00:00Z

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12805457

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164784

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