Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.
about
Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A proteinSimultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus TherapyStructural and Functional Properties of the Hepatitis C Virus p7 ViroporinRegulation of hepatic innate immunity by hepatitis C virusStructures of hepatitis C virus nonstructural proteins required for replicase assembly and functionIdentification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4BHepatitis C virus NS4B carboxy terminal domain is a membrane binding domainHelicase inhibitors as specifically targeted antiviral therapy for hepatitis CAn Amphipathic -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane AssociationCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationThree conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implicationsStructural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion AssemblyDiscovery of an allosteric mechanism for the regulation of HCV NS3 protein functionA macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length targetNS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane TopologiesMechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidolNatural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α18Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors.Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain.Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6Determinants for membrane association of the hepatitis C virus NS2 protease domain.Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of hepatitis C virus.Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxinHepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase.Intracellular innate immune cascades and interferon defenses that control hepatitis C virusAnalysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4BTargeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase.In silico identification and evaluation of leads for the simultaneous inhibition of protease and helicase activities of HCV NS3/4A protease using complex based pharmacophore mapping and virtual screening.Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?Hepatitis C Virus. Strategies to Evade Antiviral ResponsesRobust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Intramolecular regulation of the sequence-specific mRNA interferase activity of MazF fused to a MazE fragment with a linker cleavable by specific proteasesTunable and reversible drug control of protein production via a self-excising degron.A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis.RNA binding by the NS3 protease of the hepatitis C virusEmerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infectionHepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices
P2860
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P2860
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Structural determinants for me ...... patitis C virus NS3-4A complex
@nl
Structural determinants for me ...... atitis C virus NS3-4A complex.
@ast
Structural determinants for me ...... atitis C virus NS3-4A complex.
@en
type
label
Structural determinants for me ...... patitis C virus NS3-4A complex
@nl
Structural determinants for me ...... atitis C virus NS3-4A complex.
@ast
Structural determinants for me ...... atitis C virus NS3-4A complex.
@en
prefLabel
Structural determinants for me ...... patitis C virus NS3-4A complex
@nl
Structural determinants for me ...... atitis C virus NS3-4A complex.
@ast
Structural determinants for me ...... atitis C virus NS3-4A complex.
@en
P2093
P2860
P50
P3181
P356
P1476
Structural determinants for me ...... atitis C virus NS3-4A complex.
@en
P2093
François Penin
Hubert E Blum
Jan Martin Berke
Roland Montserret
Volker Brass
P2860
P304
14545-14550
P3181
P356
10.1073/PNAS.0807298105
P407
P577
2008-09-17T00:00:00Z