Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design
about
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymesAutosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid bindingIMP dehydrogenase: structure, mechanism, and inhibition.Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa.Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosisDifferent characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoformsA heterocyclic molecule with significant activity against dengue virusCrystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding siteBacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound ComplexesStructure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenaseCrystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-β-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domainsDetection of trans-cis flips and peptide-plane flips in protein structuresCBS domains: structure, function, and pathology in human proteinsBroad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferonMycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular CompoundsStructural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA capA novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.Cystathionine β-synthase (CBS) domains 1 and 2 fulfill different roles in ionic strength sensing of the ATP-binding cassette (ABC) transporter OpuA.Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.The cystathionine-β-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels.Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.IMP dehydrogenase-linked retinitis pigmentosa.Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics.Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase.Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside.Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design.Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP.PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain.A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.Specific biotinylation of IMP dehydrogenaseIMPDHII protein inhibits Toll-like receptor 2-mediated activation of NF-kappaB.An insight to the dynamics of conserved water-mediated salt bridge interaction and interdomain recognition in hIMPDH isoforms.IMPDH as a biological probe for RNA antiviral drug discovery: synthesis, enzymology, molecular docking, and antiviral activity of new ribonucleosides with surrogate bases.Conserved water-mediated recognition and dynamics of NAD+ (carboxamide group) to hIMPDH enzyme: water mimic approach toward the design of isoform-selective inhibitor.An insight to the dynamics of conserved water molecular triad in IMPDH II (human): recognition of cofactor and substrate to catalytic Arg 322.Inhibitors of inosine monophosphate dehydrogenase: probes for antiviral drug discovery.Conserved water mediated recognition and the dynamics of active site Cys 331 and Tyr 411 in hydrated structure of human IMPDH-II.
P2860
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P2860
Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of human typ ...... ligand binding and drug design
@ast
Crystal structure of human typ ...... ligand binding and drug design
@en
Crystal structure of human typ ...... ligand binding and drug design
@nl
type
label
Crystal structure of human typ ...... ligand binding and drug design
@ast
Crystal structure of human typ ...... ligand binding and drug design
@en
Crystal structure of human typ ...... ligand binding and drug design
@nl
prefLabel
Crystal structure of human typ ...... ligand binding and drug design
@ast
Crystal structure of human typ ...... ligand binding and drug design
@en
Crystal structure of human typ ...... ligand binding and drug design
@nl
P2093
P2860
P356
P1476
Crystal structure of human typ ...... ligand binding and drug design
@en
P2093
B M Goldstein
G D Markham
K Vanderveen
M D Strickler
P2860
P304
P356
10.1073/PNAS.96.7.3531
P407
P577
1999-03-30T00:00:00Z