Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon - Wikidata - awgldk - TriplyDB

Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

http://www.wikidata.org/entity/Q28344042

about

Bateman domains and adenosine derivatives form a binding contract IMP dehydrogenase: structure, mechanism, and inhibition.Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy Ribavirin: Past, present and future Curing a viral infection by targeting the host: the example of cyclophilin inhibitors Ribavirin Induces Error-Prone Replication of GB Virus B in Primary Tamarin Hepatocytes Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons.Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture Synergistic In Vitro Interactions between Alpha Interferon and Ribavirin against Bovine Viral Diarrhea Virus and Yellow Fever Virus as Surrogate Models of Hepatitis C Virus Replication Analysis of Ribavirin Mutagenicity in Human Hepatitis C Virus Infection Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites Longitudinal study of a human drug-induced model of autoantibody to cytoplasmic rods/rings following HCV therapy with ribavirin and interferon-α Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2 A review of treatment modalities for Middle East Respiratory Syndrome.Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.Prodrug activation by Cryptosporidium thymidine kinase.Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system.An update on respiratory syncytial virus antiviral agents.The Efficacy of Mizoribine (Inosine Monophosphate Dehydrogenase Inhibitor) for ANCA-Associated Vasculitis with Hepatitis B Virus Carrier Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo.Mechanisms of action of ribavirin in antiviral therapies.A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus Antiviral effects against EV71 of pimprinine and its derivatives isolated from Streptomyces sp Emerging therapies of hepatitis B and C.Hepatitis C virus therapies: current treatments, targets and future perspectives.High-content image-based screening of a signal transduction pathway inhibitor small-molecule library against highly pathogenic RNA viruses.Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.In search of a small-molecule inhibitor for respiratory syncytial virus.Antisense approaches for inhibiting respiratory syncytial virus.Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication.(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.Emerging drugs for respiratory syncytial virus infection.Recent advances in diagnosis, prevention, and treatment of human respiratory syncytial virus.Novel therapies for an old virus: treatment of RSV infections in the 21st Century.Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics.

P2860

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P2860

Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

http://www.wikidata.org/entity/Q28344042

description

2000 nî lūn-bûn

@nan

2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի ապրիլին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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type

label

Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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AAC.44.4.859-866.2000

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Antimicrobial Agents and Chemotherapy

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Broad-spectrum antiviral activ ...... ditivity with alpha interferon

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A D Kwong

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J Jain

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W Markland

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P2860

Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo

Mechanism of La Crosse virus inhibition by ribavirin.

A three-dimensional model to analyze drug-drug interactions.

Biochemistry and clinical applications of ribavirin.

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859-866

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4

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