The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
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Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMPCrystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeletonCan sequence determine function?Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrateCrystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylaseStructural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylaseStructural Basis for Substrate Specificity in Phosphate Binding (β/α) 8 -Barrels: d -Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12 † ‡Structural Characterization of the Molecular Events during a Slow Substrate–Product Transition in Orotidine 5′-Monophosphate DecarboxylaseMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active ConformationStructural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline DecarboxylaseThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationFrsA functions as a cofactor-independent decarboxylase to control metabolic fluxMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMEmergent Decarboxylase Activity and Attenuation of α/β-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in TomatoSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseProton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituentMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.Enhancing MAD F(A) data for substructure determination.Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing.Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase.Novel reversible indole-3-carboxylate decarboxylase catalyzing nonoxidative decarboxylation.Protein function annotation with Structurally Aligned Local Sites of Activity (SALSAs)Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMPQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysisPolarization in the structures of uracil and thiouracils: Implication for binding with orotidine 5'-monophosphate decarboxylaseCooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily.Crystal structure of uroporphyrinogen decarboxylase from Bacillus subtilisMechanisms and free energies of enzymatic reactions.Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography.Indiscriminate binding by orotidine 5'-phosphate decarboxylase of uridine 5'-phosphate derivatives with bulky anionic c6 substituents.Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.Organization of Nucleotides in Different Environments and the Formation of Pre-Polymers.Development and application of ab initio QM/MM methods for mechanistic simulation of reactions in solution and in enzymes.Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.
P2860
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P2860
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
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2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@ast
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@en
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@nl
type
label
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@ast
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@en
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@nl
prefLabel
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@ast
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@en
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@nl
P2093
P2860
P356
P1476
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase
@en
P2093
C Kinsland
S E Ealick
T C Appleby
T P Begley
P2860
P304
P356
10.1073/PNAS.259441296
P407
P577
2000-02-29T00:00:00Z