Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP
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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active ConformationMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the EnzymeAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseEnzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networksProton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituentMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.Enzymatic Catalysis of Proton Transfer and Decarboxylation Reactions.The stability of aryl carbanions derived from pyridine N-oxide: the role of resonance in stabilizing aryl anions.Activation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase.The discovery of 5-formylcytosine in embryonic stem cell DNA.Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces.On catalytic preorganization in oxyanion holes: highlighting the problems with the gas-phase modeling of oxyanion holes and illustrating the need for complete enzyme models.Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.OMP decarboxylase: phosphodianion binding energy is used to stabilize a vinyl carbanion intermediate.The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture.Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMPRate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate DecarboxylaseOrotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase.Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates.Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase.Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organismsEnzyme (re)design: lessons from natural evolution and computation.Enzyme architecture: the activating oxydianion binding domain for orotidine 5'-monophophate decarboxylase.The use of reaction timecourses to determine the level of minor contaminants in enzyme preparations.Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion.Catalytic efficiency of enzymes: a theoretical analysisSpecificity in transition state binding: the Pauling model revisited.Design of inhibitors of ODCase.Modification of purine and pyrimidine nucleosides by direct C-H bond activation.
P2860
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P2860
Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@ast
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@en
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@nl
type
label
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@ast
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@en
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@nl
prefLabel
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@ast
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@en
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@nl
P2093
P2860
P356
P1476
Formation and stability of a v ...... C-6 proton of enzyme-bound UMP
@en
P2093
Bryant M Wood
John A Gerlt
Tina L Amyes
P2860
P304
P356
10.1021/JA710384T
P407
P577
2008-02-06T00:00:00Z