Site-directed ligand discovery - Wikidata - awgldk - TriplyDB

Site-directed ligand discovery

Site-directed ligand discovery

http://www.wikidata.org/entity/Q27626501

about

Electrophilic affibodies forming covalent bonds to protein targets Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks Fine-tuning multiprotein complexes using small molecules Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides The pharmacological landscape and therapeutic potential of serine hydrolases Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-In situ assembly of enzyme inhibitors using extended tethering Binding of small molecules to an adaptive protein-protein interface Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry Structural model of the p14/SF3b155{middle dot}branch duplex complex In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction Turning a protein kinase on or off from a single allosteric site via disulfide trapping.Stereo- and regioselective azide/alkyne cycloadditions in carbonic anhydrase II via tethering, monitored by crystallography and mass spectrometry Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface Using a Fragment-Based Approach To Target Protein-Protein Interactions Ordering a Dynamic Protein Via a Small-Molecule Stabilizer Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121 Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions Motif mediated protein-protein interactions as drug targets Navigating chemical space for biology and medicine Theory of free energy and entropy in noncovalent binding Directed discovery of bivalent peptide ligands to an SH3 domain Proteome-wide covalent ligand discovery in native biological systems Dependence of Effective Molarity on Linker Length for an Intramolecular Protein−Ligand System Small-molecule inhibitors of protein-protein interactions: progressing towards the dream Modeling functional changes to Escherichia coli thymidylate synthase upon single residue replacements: a structure-based approach Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.Discovery of an allosteric site in the caspases Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor.Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking.Novel acetylcholinesterase target site for malaria mosquito control.Genetic selection for peptide inhibitors of angiogenin.Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides.Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

P2860

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P2860

Site-directed ligand discovery

http://www.wikidata.org/entity/Q27626501

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Site-directed ligand discovery

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Site-directed ligand discovery

@en

Site-directed ligand discovery

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type

label

Site-directed ligand discovery

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Site-directed ligand discovery

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Site-directed ligand discovery

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prefLabel

Site-directed ligand discovery

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Site-directed ligand discovery

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Site-directed ligand discovery

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P2860

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P3181

P356

PNAS.97.17.9367

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Site-directed ligand discovery

@en

P2093

A C Braisted

http://www.w3.org/2001/XMLSchema#string

D A Erlanson

http://www.w3.org/2001/XMLSchema#string

D R Raphael

http://www.w3.org/2001/XMLSchema#string

E M Gordon

http://www.w3.org/2001/XMLSchema#string

J A Wells

http://www.w3.org/2001/XMLSchema#string

M Randal

http://www.w3.org/2001/XMLSchema#string

R M Stroud

http://www.w3.org/2001/XMLSchema#string

P2860

On the attribution and additivity of binding energies

Improved methods for building protein models in electron density maps and the location of errors in these models

Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

The additivity of substrate fragments in enzyme-ligand binding

Structure-based design of inhibitors specific for bacterial thymidylate synthase

The finer things in X-ray diffraction data collection

The CCP4 suite: programs for protein crystallography

Preferential heterodimer formation by isolated leucine zippers from fos and jun

Structure-based discovery of inhibitors of thymidylate synthase

P304

9367-72

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scholarly article

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3308142

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10.1073/PNAS.97.17.9367

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P433

17

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P478

97

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P577

2000-08-15T00:00:00Z

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P5875

12376996

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P698

10944209

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P932

16870

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