Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
about
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systemsThe 1.5-Å Structure of XplA-heme, an Unusual Cytochrome P450 Heme Domain That Catalyzes Reductive Biotransformation of Royal Demolition ExplosiveStructural Evidence for Enhancement of Sequential Vitamin D3 Hydroxylation Activities by Directed Evolution of Cytochrome P450 Vitamin D3 HydroxylaseMight ART Adherence Estimates Be Improved by Combining Biomarker and Self-Report Data?Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine.Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.Structural basis for ligand promiscuity in cytochrome P450 3A4.Systematic placement of structural water molecules for improved scoring of protein-ligand interactionsAnalysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers.Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry.Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analoguesCrystallization and preliminary X-ray diffraction studies of vitamin D3 hydroxylase, a novel cytochrome P450 isolated from Pseudonocardia autotrophica.Defining targets for investigating the pharmacogenomics of adverse drug reactions to antifungal agents.Conformational plasticity and structure/function relationships in cytochromes P450.Diversity of P450 enzymes in the biosynthesis of natural productsResolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.Structural analysis of SgvP involved in carbon-sulfur bond formation during griseoviridin biosynthesis.Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei.Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.Cytotoxic doses of ketoconazole affect expression of a subset of hepatic genes.Ketoconazole-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in rabbit corneal epithelial cells (SIRC).
P2860
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P2860
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@ast
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@en
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@nl
type
label
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@ast
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@en
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@nl
prefLabel
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@ast
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@en
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@nl
P2093
P356
P1476
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
@en
P2093
J R Cupp-Vickery
K McGee-Estrada
P304
P356
10.1006/JMBI.2001.4803
P407
P577
2001-08-03T00:00:00Z