Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.
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Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray CrystallographyStructural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic ActivityX-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocketStructural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6Evolutionary history of a specialized p450 propane monooxygenaseStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexesTwo-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes.Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding.Interactions of cytochrome P450s with their ligands.A malleable catalyst dominates the metabolism of drugs.Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopyStructural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry.Substrate binding to cytochromes P450.Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1.tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance.Plasticity of CYP2B enzymes: structural and solution biophysical methods.Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.Re-engineering of CYP2C9 to probe acid-base substrate selectivityHeat-shock protein 90 (Hsp90) as anticancer target for drug discovery: an ample computational perspective.Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzymeDecreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.Differential effects of ethanol on spectral binding and inhibition of cytochrome P450 3A4 with eight protease inhibitors antiretroviral drugs.Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and backUse of phenoxyaniline analogs to generate biochemical insights into polybrominated diphenyl ether interaction with CYP2B enzymes.
P2860
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P2860
Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.
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2006 nî lūn-bûn
@nan
2006年の論文
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2006年学术文章
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2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
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@zh-sg
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@yue
2006年學術文章
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name
Conformational flexibility of ...... namics and molecular modeling.
@en
Conformational flexibility of ...... namics and molecular modeling.
@nl
type
label
Conformational flexibility of ...... namics and molecular modeling.
@en
Conformational flexibility of ...... namics and molecular modeling.
@nl
prefLabel
Conformational flexibility of ...... namics and molecular modeling.
@en
Conformational flexibility of ...... namics and molecular modeling.
@nl
P2093
P2860
P356
P1476
Conformational flexibility of ...... namics and molecular modeling.
@en
P2093
B K Muralidhara
Christopher C Chin
James R Halpert
Surendra Negi
Werner Braun
P2860
P304
P356
10.1074/JBC.M509696200
P407
P577
2006-01-26T00:00:00Z