A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism
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Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptidesThe Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray DiffractionStatistical Coupling Analysis of Aspartic Proteinases Based on Crystal Structures of the Trichoderma reesei Enzyme and Its Complex with Pepstatin ARapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinementX-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase): perdeuteration of proteins for neutron diffractionCamel and bovine chymosin: the relationship between their structures and cheese-making propertiesStructure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistryFragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial ChemistryGrassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.Large crystal growth by thermal control allows combined X-ray and neutron crystallographic studies to elucidate the protonation states in Aspergillus flavus urate oxidase.Neutron structure and mechanistic studies of diisopropyl fluorophosphatase (DFPase)Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.Large-volume protein crystal growth for neutron macromolecular crystallographyHydrogen atoms in proteins: positions and dynamics.Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.Preliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris.Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor.Preliminary time-of-flight neutron diffraction study of human deoxyhemoglobin.Neutron crystallography: opportunities, challenges, and limitationsA preliminary neutron diffraction study of gamma-chymotrypsinNeutron crystallographic study on rubredoxin from Pyrococcus furiosus by BIX-3, a single-crystal diffractometer for biomacromolecules.Microbial aspartic proteases: current and potential applications in industry.Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.Crystallization of nepenthesin I using a low-pH crystallization screen.Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.Assigning the protonation states of the key aspartates in β-Secretase using QM/MM X-ray structure refinementNeutron scattering techniques and applications in structural biology.Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.Switching of turn conformation in an aspartate anion peptide fragment by NH . . . O- hydrogen bonds.Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.Fragment-based similarity searching with infinite color space.
P2860
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P2860
A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@ast
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@en
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@nl
type
label
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@ast
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@en
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@nl
prefLabel
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@ast
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@en
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@nl
P2093
P3181
P356
P1433
P1476
A neutron Laue diffraction stu ...... aspartic proteinase mechanism
@en
P2093
P304
P3181
P356
10.1021/BI010626H
P407
P577
2001-11-06T00:00:00Z