Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
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Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysisWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseLoss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer diseaseToward the structure of presenilin/γ-secretase and presenilin homologsThe Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related GenesThe crystal structure of GXGD membrane protease FlaKStructural investigation of the C-terminal catalytic fragment of presenilin 1Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludisAssembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.The secretases: enzymes with therapeutic potential in Alzheimer disease.Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.Presenilin is the molecular target of acidic γ-secretase modulators in living cells.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's diseaseMutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteasesAmyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.The dynamic conformational landscape of gamma-secretase.Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.Membrane-embedded protease poses for photoshoot.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.From rhomboid function to structure and back againChemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's DiseaseStructural principles of intramembrane proteasesSubstrate specificity of gamma-secretase and other intramembrane proteases.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Toward structural elucidation of the gamma-secretase complex.Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteasesIntramembrane proteolysisIntramembrane proteolysis by gamma-secretase.APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexesStructure and mechanism of intramembrane protease.Intramembrane-cleaving proteases.Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.
P2860
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P2860
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Contribution of presenilin tra ...... n the gamma-secretase complex.
@en
Contribution of presenilin tra ...... n the gamma-secretase complex.
@nl
type
label
Contribution of presenilin tra ...... n the gamma-secretase complex.
@en
Contribution of presenilin tra ...... n the gamma-secretase complex.
@nl
prefLabel
Contribution of presenilin tra ...... n the gamma-secretase complex.
@en
Contribution of presenilin tra ...... n the gamma-secretase complex.
@nl
P2860
P356
P1476
Contribution of presenilin tra ...... n the gamma-secretase complex.
@en
P2093
Alexandra Tolia
Lucía Chávez-Gutiérrez
P2860
P304
27633-27642
P356
10.1074/JBC.M604997200
P407
P577
2006-07-14T00:00:00Z