High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin
about
Evidence for a high-spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylaseMechanism of aromatic amino acid hydroxylationStructure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stabilityMechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic AnalysisStructural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophilaReduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificityPurification, crystallization and crystallographic analysis of Dictyostelium discoideum phenylalanine hydroxylase in complex with dihydrobiopterin and FeIII.Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases.A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulationLinking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuriaProton-coupled electron transfer of ruthenium(III)-pterin complexes: a mechanistic insightStructural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivationAccurate prediction of functional effects for variants by combining gradient tree boosting with optimal neighborhood properties.A Mononuclear Carboxylate-Rich Oxoiron(IV) Complex: a Structural and Functional Mimic of TauD Intermediate 'J'Role of the phenylalanine-hydroxylating system in aromatic substance degradation and lipid metabolism in the oleaginous fungus Mortierella alpinaPulsed EPR study of amino acid and tetrahydropterin binding in a tyrosine hydroxylase nitric oxide complex: evidence for substrate rearrangements in the formation of the oxygen-reactive complex.Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.Allosteric regulation of phenylalanine hydroxylase.Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation.Stabilization of tryptophan hydroxylase 2 by l-phenylalanine-induced dimerization.VTVH-MCD and DFT studies of thiolate bonding to [FeNO]7/[FeO2]8 complexes of isopenicillin N synthase: substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes.Kinetic mechanism of phenylalanine hydroxylase: intrinsic binding and rate constants from single-turnover experiments.Effects of ligands on the mobility of an active-site loop in tyrosine hydroxylase as monitored by fluorescence anisotropy.Uncoupled forms of tyrosine hydroxylase unmask kinetic isotope effects on chemical steps.Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases.Substrate-induced conformational transition in human phenylalanine hydroxylase as studied by surface plasmon resonance analyses: the effect of terminal deletions, substrate analogues and phosphorylation.Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad.The regulatory domain of human tryptophan hydroxylase 1 forms a stable dimerA flexible loop in tyrosine hydroxylase controls coupling of amino acid hydroxylation to tetrahydropterin oxidation.Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity.Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations.Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis.
P2860
Q24594412-DE6D52E8-C2BD-4A1E-9B0F-2AEB26A02650Q24673681-2D4565E2-FB0D-4F54-AD5C-2984D2F9D739Q27645041-E4DB72ED-F858-4B18-BCB5-0DF6AA688D17Q27662396-37C911C8-C221-461E-AEAD-C666C8254B05Q27680642-25AA79D4-B726-41EE-8D6F-2EB782133B1AQ28578299-6A874210-C61D-4E98-869D-B7CD01F00BE6Q33780181-CABB4E1D-1842-49BD-BFD1-07CF32F87AD6Q34166879-3149F25C-322F-4381-AB23-53A9B955801DQ34463948-DD7C4AC4-9074-408E-8AD9-A008694A5E10Q34541520-8F521D7B-A03B-4DDF-8770-28059EC4BED9Q35079956-4678FA0F-A1E5-4E9B-A97D-BD7CA6539F1CQ35446730-D059C790-D578-490F-99B4-8E3FDDEF5C08Q35792429-A9579F82-6FB6-4686-B49F-51C3231A25ABQ36405487-FD3FDA1D-05D6-4B85-BFB6-DAB0430F5527Q36482216-E72A5868-C7F5-4BF4-8CB8-E712030F61C8Q36936418-AD86964D-88D9-4DE8-895A-B855560AF260Q37518382-70D84324-DB39-49E1-ADCE-89A16587E548Q37695699-4BAA5FDD-F381-43EA-A7D8-D316E6C487C4Q37946639-A451B667-4E8F-472F-9B83-F204146B1F67Q38691976-25B0AF2F-3BAE-44A6-84E0-33DE9070044BQ41366766-6C825223-22D8-461C-972F-DD7FD1225D59Q41808909-52B0CA04-871D-4CF6-A8F8-FA6CCB9BFCA3Q41817640-2858CB73-E8AF-4521-9D52-6468BF7EA6FFQ41901951-5FC03BCA-34DE-4090-9492-1EF6B9D82C06Q42016853-835F2720-79B6-47B4-B0DF-4BC2EF2AA168Q42036836-036E847E-BF48-491F-A699-C11C36F72CA4Q42104266-4F315142-84F4-4820-BD91-24DDBAFBEF85Q42128398-2FB1D36B-5FD4-4473-8321-A76F580ECA18Q42155037-D5193005-4990-45B8-9A9A-D7925A61BC59Q42252971-4A93D0CA-1E4E-4A05-B9FC-94B6A8C7A353Q42758377-4BEB5EF2-4089-4049-8CF5-EE34BAD18DB7Q43090007-8623345A-5B0B-4A8D-9BF5-5129131834AAQ44439495-BB46C6F2-9C95-4AB0-AEAA-E8E44445C54EQ44827080-E6365520-5E8C-4340-9B02-42C92E6D804D
P2860
High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@ast
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@en
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@nl
type
label
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@ast
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@en
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@nl
prefLabel
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@ast
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@en
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@nl
P2093
P3181
P356
P1476
High resolution crystal struct ...... mplex with tetrahydrobiopterin
@en
P2093
P304
P3181
P356
10.1006/JMBI.2001.5061
P407
P577
2001-11-23T00:00:00Z