Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis.
about
Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactorA new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeuticsLoss of function in phenylketonuria is caused by impaired molecular motions and conformational instabilityDomain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.Phenylalanine hydroxylase: function, structure, and regulation.Tetrahydrobiopterin, its mode of action on phenylalanine hydroxylase, and importance of genotypes for pharmacological therapy of phenylketonuria.Functional and structural characterization of novel mutations and genotype-phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy.
P2860
Q24293412-613B11EE-C9C4-4AE6-AE1B-4DB9EC875CA2Q24617497-7AFF3A4A-F487-4C2E-B731-077C2EF9C8DFQ36744649-CA36177D-FE91-482B-B38C-C0B313BB2E50Q36977345-10776D51-148F-4CB1-9516-9B08AB04AF4BQ37695699-F68B0DC2-7076-4DA7-BF40-60187F39C6D9Q38086186-8E402D4C-0228-4B9B-AAC0-910A264D1E77Q38096351-71B8ED08-D297-4F0A-9C31-57FAC53B2E17Q44940206-4601DB6F-58BF-42D2-9C8D-4D44DEBAB1C5
P2860
Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Probing the role of crystallog ...... se by single-site mutagenesis.
@en
Probing the role of crystallog ...... se by single-site mutagenesis.
@nl
type
label
Probing the role of crystallog ...... se by single-site mutagenesis.
@en
Probing the role of crystallog ...... se by single-site mutagenesis.
@nl
prefLabel
Probing the role of crystallog ...... se by single-site mutagenesis.
@en
Probing the role of crystallog ...... se by single-site mutagenesis.
@nl
P2093
P2860
P356
P1476
Probing the role of crystallog ...... se by single-site mutagenesis.
@en
P2093
Anne Jorunn Stokka
João Filipe Barroso
Raquel Negrão Carvalho
Torgeir Flatmark
P2860
P304
26571-26580
P356
10.1074/JBC.M400879200
P407
P577
2004-04-01T00:00:00Z