Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
about
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseIdentification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2The protein common interface database (ProtCID)--a comprehensive database of interactions of homologous proteins in multiple crystal formsOmi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosisAllosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritimaStructural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domainStructural and functional analysis of the PDZ domains of human HtrA1 and HtrA3OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition MechanismSubstrate-induced remodeling of the active site regulates human HTRA1 activityMolecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell EnvelopeNewly folded substrates inside the molecular cage of the HtrA chaperone DegQThe structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteasesThe yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cellsThe tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell deathThe mitochondrial serine protease HtrA2/Omi: an overviewOmi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucBNeuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in miceDevelopmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signalingStructural and Functional Analysis of Human HtrA3 Protease and Its SubdomainsOmi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's diseaseMolecular mechanisms of caspase regulation during apoptosisMolecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma.Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system.The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction.A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor.Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.Soluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coliPhosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.A new principle of oligomerization of plant DEG7 protease based on interactions of degenerated protease domainsThe inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity.
P2860
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P2860
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structural insights into the p ...... rial serine protease HtrA2/Omi
@ast
Structural insights into the p ...... rial serine protease HtrA2/Omi
@en
Structural insights into the p ...... rial serine protease HtrA2/Omi
@nl
type
label
Structural insights into the p ...... rial serine protease HtrA2/Omi
@ast
Structural insights into the p ...... rial serine protease HtrA2/Omi
@en
Structural insights into the p ...... rial serine protease HtrA2/Omi
@nl
prefLabel
Structural insights into the p ...... rial serine protease HtrA2/Omi
@ast
Structural insights into the p ...... rial serine protease HtrA2/Omi
@en
Structural insights into the p ...... rial serine protease HtrA2/Omi
@nl
P2093
P921
P3181
P356
P1476
Structural insights into the p ...... rial serine protease HtrA2/Omi
@en
P2093
Emad S Alnemri
Jia-Wei Wu
Jijie Chai
Pingwei Li
Srinivasa M Srinivasula
ZhiJia Zhang
P2888
P304
P3181
P356
10.1038/NSB795
P407
P50
P577
2002-06-01T00:00:00Z
P5875
P6179
1046644737