Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
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Parkinson's disease: from monogenic forms to genetic susceptibility factorsThe mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawalBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)PINK1 cleavage at position A103 by the mitochondrial protease PARL.THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell deathNo death without life: vital functions of apoptotic effectorsOxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseThe Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/OmiCross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseMitochondrial Quality Control and Muscle Mass MaintenanceStructural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domainThe yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.Mitochondrial protein quality control: the mechanisms guarding mitochondrial healthThe protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathwayThe mitochondrial serine protease HtrA2/Omi: an overviewMitochondrial quality control in the myocardium: cooperation between protein degradation and mitophagyCell biology. Metabolic control of cell deathIdebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout miceUnique anti-apoptotic activity of EAAC1 in injured motor neuronsOmi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's diseaseDrosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from ParkinGenetic susceptibility in Parkinson's diseaseSequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration.Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice.Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA)Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration.Sept4/ARTS is required for stem cell apoptosis and tumor suppression.Signaling the mitochondrial unfolded protein response.A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor.Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases.Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
P2860
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P2860
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
description
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im November 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/11/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/11/01)
@nl
наукова стаття, опублікована в листопаді 2004
@uk
مقالة علمية (نشرت في نوفمبر 2004)
@ar
name
Neuroprotective role of the Re ...... d by targeted deletion in mice
@ast
Neuroprotective role of the Re ...... d by targeted deletion in mice
@en
Neuroprotective role of the Re ...... d by targeted deletion in mice
@nl
type
label
Neuroprotective role of the Re ...... d by targeted deletion in mice
@ast
Neuroprotective role of the Re ...... d by targeted deletion in mice
@en
Neuroprotective role of the Re ...... d by targeted deletion in mice
@nl
prefLabel
Neuroprotective role of the Re ...... d by targeted deletion in mice
@ast
Neuroprotective role of the Re ...... d by targeted deletion in mice
@en
Neuroprotective role of the Re ...... d by targeted deletion in mice
@nl
P2093
P2860
P50
P1476
Neuroprotective role of the Re ...... d by targeted deletion in mice
@en
P2093
Alastair Morrison
Alejandro Abuin
Alison Martin
Caretha L. Creasy
Evelyn Grau
George P. Livi
Hitoshi Okada
Iain Hargreaves
Kristina Klupsch
Martin Geppert
P2860
P304
P356
10.1128/MCB.24.22.9848-9862.2004
P407
P577
2004-11-01T00:00:00Z