Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
about
A structure filter for the Eukaryotic Linear Motif Resource.The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complexE2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferasesMotif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationShort linear motifs - ex nihilo evolution of protein regulationDesign principles underpinning the regulatory diversity of protein kinasesFluorescent peptide biosensor for probing the relative abundance of cyclin-dependent kinases in living cellsAlternative binding modes of an inhibitor to two different kinasesAn overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma proteinThe structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent rolesCiz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitroA structural bioinformatics approach for identifying proteins predisposed to bind linear epitopes on pre-selected target proteinsPlasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogonyIdentification of an hexapeptide that binds to a surface pocket in cyclin A and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin A.Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.Substrate and docking interactions in serine/threonine protein kinasesDiscovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding.Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1.PONDR-FIT: a meta-predictor of intrinsically disordered amino acidsPathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesRational design of a cyclin A fluorescent peptide sensor.Protein binding specificity versus promiscuity.Retro-MoRFs: identifying protein binding sites by normal and reverse alignment and intrinsic disorder predictionBinding of two intrinsically disordered peptides to a multi-specific protein: a combined Monte Carlo and molecular dynamics studyPUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry.Intrinsic disorder in scaffold proteins: getting more from lessSelectivity and potency of cyclin-dependent kinase inhibitors.A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.Targeting the cyclin-binding groove site to inhibit the catalytic activity of CDK2/cyclin A complex using p27(KIP1)-derived peptidomimetic inhibitorsDynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Molecular dynamic simulation insights into the normal state and restoration of p53 function.Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha.Long range recognition and selection in IDPs: the interactions of the C-terminus of p53Docking flexible peptide to flexible protein by molecular dynamics using two implicit-solvent models: an evaluation in protein kinase and phosphatase systems.Intrinsically disordered regions of p53 family are highly diversified in evolution.Variation of free-energy landscape of the p53 C-terminal domain induced by acetylation: Enhanced conformational sampling.The tumor suppressor p53: from structures to drug discovery.Diversity within the pRb pathway: is there a code of conduct?Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery.
P2860
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P2860
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@ast
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@en
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@nl
type
label
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@ast
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@en
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@nl
prefLabel
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@ast
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@en
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@nl
P2093
P3181
P356
P1433
P1476
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
@en
P2093
Edward D Lowe
Kin Yip Cheng
Louise N Johnson
Martin E M Noble
Nick R Brown
Sheraz Gul
P304
P3181
P356
10.1021/BI0268910
P407
P577
2002-12-31T00:00:00Z