Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha. - Wikidata - awgldk - TriplyDB

Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha.

Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha.

http://www.wikidata.org/entity/Q36519173

about

Structural and functional diversity of the microbial kinome Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model Automatic discovery of cross-family sequence features associated with protein function.JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships Redox regulation of FoxO transcription factors Design principles underpinning the regulatory diversity of protein kinases The Cryptosporidium parvum Kinome The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γ Substrate and docking interactions in serine/threonine protein kinases Co-conserved features associated with cis regulation of ErbB tyrosine kinases.Phosphorylation of the transcription activator CLOCK regulates progression through a ∼ 24-h feedback loop to influence the circadian period in Drosophila.Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks.Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery Inference of Functionally-Relevant N-acetyltransferase Residues Based on Statistical Correlations.Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation.Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases.The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.The annotation of both human and mouse kinomes in UniProtKB/Swiss-Prot: one small step in manual annotation, one giant leap for full comprehension of genomes.Identification, nomenclature, and evolutionary relationships of mitogen-activated protein kinase (MAPK) genes in soybean.TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma.Activation, regulation, and inhibition of DYRK1A.Regulation of splicing by SR proteins and SR protein-specific kinases.GSK-3β, a pivotal kinase in Alzheimer disease.KinView: a visual comparative sequence analysis tool for integrated kinome research.The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters Through a Rho-Dependent Mechanism.Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors.

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P2860

Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha.

http://www.wikidata.org/entity/Q36519173

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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type

label

Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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prefLabel

Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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Protein Science

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Evolutionary constraints assoc ...... GSK, SRPK, DYRK, and CK2alpha.

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P2093

Andrew F Neuwald

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Natarajan Kannan

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P2860

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

Structural basis of cyclin-dependent kinase activation by phosphorylation

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

The protein kinase complement of the human genome

The Protein Data Bank

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.

GSK-3: tricks of the trade for a multi-tasking kinase

Processive phosphorylation of alternative splicing factor/splicing factor 2

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme

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2059-2077

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scholarly article

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10.1110/PS.04637904

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8

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13

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8437013

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15273306

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2279817

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