Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
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Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolatesHuman glycinamide ribonucleotide transformylase: active site mutants as mechanistic probesDiscovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylaseBiological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide TransformylaseCrystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterTargeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerizationCrystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance.Structural biology of the purine biosynthetic pathway.6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyProtein preparation, crystallization and preliminary crystallographic studies of Bacillus subtilis glycinamide ribonucleotide transformylaseTumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA.Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.
P2860
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P2860
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@ast
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@en
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@nl
type
label
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@ast
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@en
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@nl
prefLabel
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@ast
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@en
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@nl
P2093
P356
P1433
P1476
Rational design, synthesis, ev ...... c-5,6,7,8-tetrahydrofolic acid
@en
P2093
Ali Tavassoli
Arthur J Olson
Chenglong Li
Dale L Boger
Joel Desharnais
Lata T Gooljarsingh
Michael P Hedrick
Stephen J Benkovic
Thomas H Marsilje
P304
P356
10.1021/BI034219C
P407
P577
2003-05-27T00:00:00Z