Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter
about
Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyAntivitamins for Medicinal Applications.The influence of intramolecular sulfur-lone pair interactions on small-molecule drug design and receptor binding.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
P2860
Q36369109-9045BE1C-E05F-4106-A2DB-70A1EFB336A3Q36467564-45022A42-4B11-481E-814A-FC78DC75039BQ36467569-1FD2E821-B415-4714-BE54-BC9FA4AC424EQ37246257-01EB01EB-6864-4A6C-B546-9DBBED0B27B5Q38503308-6AC75DAD-A73F-4999-BC41-263C2A7DF139Q46091880-24C34F49-4F9A-4BEB-AEA1-6E56CA8CCE95Q50062142-3978ACBC-1EBE-453B-940C-28FDAC09B833Q51730395-DAC23C5E-041C-48B1-A93F-942A081449ABQ52559376-091C232B-6AD0-4CBC-A25F-032AF1A8A08B
P2860
Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Structure-activity profiles of ...... ton-coupled folate transporter
@ast
Structure-activity profiles of ...... ton-coupled folate transporter
@en
Structure-activity profiles of ...... ton-coupled folate transporter
@nl
type
label
Structure-activity profiles of ...... ton-coupled folate transporter
@ast
Structure-activity profiles of ...... ton-coupled folate transporter
@en
Structure-activity profiles of ...... ton-coupled folate transporter
@nl
prefLabel
Structure-activity profiles of ...... ton-coupled folate transporter
@ast
Structure-activity profiles of ...... ton-coupled folate transporter
@en
Structure-activity profiles of ...... ton-coupled folate transporter
@nl
P2093
P2860
P356
P1476
Structure-activity profiles of ...... ton-coupled folate transporter
@en
P2093
Adrianne Wallace
Aleem Gangjee
Christina George
Larry H Matherly
Mike R Wilson
Steven Orr
Zhanjun Hou
P2860
P304
P356
10.1021/JM501113M
P407
P577
2014-09-19T00:00:00Z