Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
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Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterDeterminants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyEnhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expressionStructural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates.Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).
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Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
@en
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
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type
label
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
@en
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
@nl
prefLabel
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
@en
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
@nl
P2093
P2860
P356
P1476
Tumor-targeting with novel non ...... urine nucleotide biosynthesis.
@en
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Aleem Gangjee
Christina Cherian
Larry H Matherly
Shermaine Mitchell-Ryan
Steven Orr
Yiqiang Wang
Zhanjun Hou
P2860
P304
P356
10.1021/JM401139Z
P407
P577
2013-10-30T00:00:00Z