Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
about
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesisRibosomal Antibiotics: Contemporary ChallengesAntibiotics that target protein synthesisThe Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and GirodazoleStructures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortuiThe structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsStructures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionRevisiting the structures of several antibiotics bound to the bacterial ribosomeTargeting Antibiotic ResistanceThe bacterial ribosome as a target for antibioticsImpact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approachKinetics of macrolide action: the josamycin and erythromycin cases.Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in Mycobacterium tuberculosis.Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm.Molecular mechanisms by which rRNA mutations confer resistance to clindamycinPostgenomic strategies in antibacterial drug discovery.23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Equilibrium conformational dynamics in an RNA tetraloop from massively parallel molecular dynamics.Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome.Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects.Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniae23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Structural insight into functional aspects of ribosomal RNA targeting.Ribosomal tolerance and peptide bond formation.Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel.A platform for the discovery of new macrolide antibiotics.From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects.The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.Species-specific antibiotic-ribosome interactions: implications for drug development.Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation.Antibiotics and the ribosome.Structural basis for cross-resistance to ribosomal PTC antibiotics.Macrolide myths.Strategies for the design of RNA-binding small molecules.Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides.On the specificity of antibiotics targeting the large ribosomal subunit.Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.The design of novel classes of macrolides for neutrophil-dominated inflammatory diseases.Nature nurtures the design of new semi-synthetic macrolide antibiotics.
P2860
Q24606228-F9B91C96-141E-448E-8BAF-A6510464A649Q26745532-7A6EF6F2-20FC-419A-A008-CC427810FE71Q27025271-1388D515-61CA-4915-81C8-21B0DE6D5712Q27643897-F86071CB-A8DC-47BE-B973-ADD8D900D97BQ27657365-950224FD-3541-4FA4-A1D6-96826F870719Q27658997-FA94CC5A-62E8-4F7E-B298-2A072D733F45Q27664697-D3018355-CEF3-4B63-8911-8F83D05DC4E5Q27664704-803EE6E5-1498-489E-B367-78E989352BF0Q28078130-AD901012-89E0-4090-A4D5-EF99741D690AQ28279726-9CC1D4B4-587B-4D62-8CE1-CCFF10F072CDQ28533868-B3D943B8-EECF-479E-9505-C6CAE2401366Q31114758-A7D65B63-9265-42DF-A429-9C75087FAC89Q33223661-741B2309-6F8F-48C0-8072-DE71B3FDBAB5Q33224241-6AE56C11-573C-4EB6-9869-247EA5EE162FQ33722127-B67F5067-FD8A-4357-B9B4-FA9D9BE17132Q33745572-BD324C8E-1CCC-4383-8D90-2EBC2635EE4BQ33935053-897492A9-43C4-480D-B39B-2988E259E26EQ34058315-E074E22D-B9B2-4D69-B087-E19F981F0427Q34497915-4BC9AC21-812D-491C-88CD-9FECCB5F9FB0Q34576226-AFE33A80-20CC-4706-9873-6190B862E0FDQ34932518-F6175A74-C863-4661-B9B2-6160CFB80A05Q35065806-ADCA7E0F-F776-4919-BB21-29FEC801048CQ35127789-C21439E1-028C-4379-8019-A80D6E98B3E4Q35549366-454115FF-FC29-429F-8828-790E58BE1514Q35605787-9EFA92D3-70CB-4559-A35A-AA74CFF60C66Q35952044-4436B667-AA34-456A-BAE0-3C1AF2873079Q36021739-D0C39E59-E6BC-4955-B554-D2138CA1FF01Q36024306-DDB8ED79-71B7-49F6-8168-8E5EC29DC3C0Q36300790-F8337D58-FC85-4684-B27D-1FA28F8E2941Q36334935-94F9FC1F-2F0C-4DE2-9E1F-BB3885FE82E2Q36425045-80D2AD16-BAA8-481F-889F-10AE15EC39F1Q36428625-AFFAD771-3DC8-4262-B456-D33416179D6DQ37020720-0A1B3EAD-02B6-4076-8A59-DF9B494ADCEFQ37274164-D274ACA6-D8B7-4AC0-9536-D38391EAE904Q37855857-A2A445EA-A345-467C-A0E8-9B9492DA21DAQ37867497-D7D856C4-BABA-4F53-B044-C8213C7F913FQ37970717-367D845F-13CE-4D3A-B208-65FF51ADE274Q37970718-5FE7A100-9FC7-4E50-B4C1-D77C3D31E05DQ38217504-FDA5B73B-A498-45EC-98AA-FC844CD4EA72Q39023947-8412E1F8-3A5C-4B12-BECB-62E5E4695CB4
P2860
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@ast
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@en
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@nl
type
label
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@ast
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@en
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@nl
prefLabel
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@ast
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@en
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@nl
P2860
P50
P3181
P1476
Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
@en
P2093
Harly A S Hansen
P2860
P304
P3181
P356
10.1128/JB.185.14.4276-4279.2003
P407
P577
2003-07-01T00:00:00Z