Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
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Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2APerspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organismsGeneral aspects of muscle glucose uptakeStructural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange FactorsMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceDiscovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainCrystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activationTranslation of the phosphoinositide code by PI effectorsEmerging methodologies to investigate lipid-protein interactionsRole of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibitionSGK1: The Dark Side of PI3K Signaling.Development of sulfonamide AKT PH domain inhibitors.Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to inIntramolecular and intermolecular interactions of protein kinase B define its activation in vivoCa(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral headPhosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alphaIn vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.Phosphatidylinositol 3-kinase: the oncoprotein.Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.Phosphatidylserine is a critical modulator for Akt activation.Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphateMembrane recognition and targeting by lipid-binding domains.The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes.Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses.The TCL1 family of oncoproteins: co-activators of transformation.A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) DomainAll PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells.Effects of ethanol on conformational changes of Akt studied by chemical cross-linking, mass spectrometry, and (18)O labeling.
P2860
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P2860
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Binding of phosphatidylinosito ...... nduces a conformational change
@ast
Binding of phosphatidylinosito ...... nduces a conformational change
@en
Binding of phosphatidylinosito ...... nduces a conformational change
@nl
type
label
Binding of phosphatidylinosito ...... nduces a conformational change
@ast
Binding of phosphatidylinosito ...... nduces a conformational change
@en
Binding of phosphatidylinosito ...... nduces a conformational change
@nl
prefLabel
Binding of phosphatidylinosito ...... nduces a conformational change
@ast
Binding of phosphatidylinosito ...... nduces a conformational change
@en
Binding of phosphatidylinosito ...... nduces a conformational change
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Binding of phosphatidylinosito ...... nduces a conformational change
@en
P2093
Christine C Milburn
Daan M F Van Aalten
Nick C Price
P2860
P3181
P356
10.1042/BJ20031229
P407
P577
2003-11-01T00:00:00Z