Capture of an intermediate in the catalytic cycle of L-aspartate- -semialdehyde dehydrogenase
about
Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme FamilyStructural Basis for a Bispecific NADP+ and CoA Binding Site in an Archaeal Malonyl-Coenzyme A ReductaseStructures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37RvA cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathwayPurification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosisIdentification of selective enzyme inhibitors by fragment library screening.Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid.Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenaseCrystallographic and spectroscopic snapshots reveal a dehydrogenase in action.The catalytic machinery of a key enzyme in amino Acid biosynthesis.Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species.Isolation and characterization of a novel lysine racemase from a soil metagenomic libraryMolecular Modeling and Active Site Binding Mode Characterization of Aspartate β-Semialdehyde Dehydrogenase Family.Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus.Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase.Mutagenesis of Key Residues in the Binding Center of l-Aspartate-b-Semialdehyde Dehydrogenase from Escherichia coli Enhances Utilization of the Cofactor NAD(H).Shape-based virtual screening, docking, and molecular dynamics simulations to identify Mtb-ASADH inhibitors.
P2860
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P2860
Capture of an intermediate in the catalytic cycle of L-aspartate- -semialdehyde dehydrogenase
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@ast
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@en
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@nl
type
label
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@ast
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@en
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@nl
prefLabel
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@ast
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@en
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@nl
P2093
P2860
P356
P1476
Capture of an intermediate in ...... e- -semialdehyde dehydrogenase
@en
P2093
Julio Blanco
Roger A Moore
Ronald E Viola
P2860
P304
P356
10.1073/PNAS.1634958100
P407
P577
2003-10-28T00:00:00Z