Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity - Wikidata - awgldk - TriplyDB

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

http://www.wikidata.org/entity/Q27642704

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Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion Novel Insights into the Roles of Rho Kinase in Cancer Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities Rational approaches to improving selectivity in drug design Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock The oncogene c-Jun impedes somatic cell reprogramming The structure of dimeric ROCK I reveals the mechanism for ligand selectivity RSK2 Binding Models Delineate Key Features for Activity Design and synthesis of inositolphosphoglycan putative insulin mediators.The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.Remodeling of actin cytoskeleton in mouse periosteal cells under mechanical loading induces periosteal cell proliferation during bone formation.STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.Rho-kinase in development and heart failure: insights from genetic models Molecular basis for small molecule inhibition of G protein-coupled receptor kinases Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice.Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.Discovery of novel inhibitors for the treatment of glaucoma.Rho kinase, a promising drug target for neurological disorders.Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges.Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.Molecular aspects of arterial smooth muscle contraction: focus on Rho.Understanding and targeting the Rho kinase pathway in erectile dysfunction.Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis Rho kinase in the regulation of cell death and survival.Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function Cell cycle kinases predicted from conserved biophysical properties Calcium channel blocker and Rho-associated kinase activity in patients with hypertension.Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy.Signaling through Rho GTPase pathway as viable drug target.Protein kinase inhibitors: contributions from structure to clinical compounds.Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders?Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors.Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function

P2860

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P2860

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

http://www.wikidata.org/entity/Q27642704

description

2003 nî lūn-bûn

@nan

2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Protein kinase A in complex wi ...... tructural basis of selectivity

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Protein kinase A in complex wi ...... tructural basis of selectivity

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Protein kinase A in complex wi ...... tructural basis of selectivity

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type

label

Protein kinase A in complex wi ...... tructural basis of selectivity

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Protein kinase A in complex wi ...... tructural basis of selectivity

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Protein kinase A in complex wi ...... tructural basis of selectivity

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prefLabel

Protein kinase A in complex wi ...... tructural basis of selectivity

@ast

Protein kinase A in complex wi ...... tructural basis of selectivity

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Protein kinase A in complex wi ...... tructural basis of selectivity

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P356

J.STR.2003.11.002

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Protein kinase A in complex wi ...... tructural basis of selectivity

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P2093

Christine Breitenlechner

http://www.w3.org/2001/XMLSchema#string

Dirk Bossemeyer

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Hiroyoshi Hidaka

http://www.w3.org/2001/XMLSchema#string

Michael Gassel

http://www.w3.org/2001/XMLSchema#string

Richard A Engh

http://www.w3.org/2001/XMLSchema#string

Robert Huber

http://www.w3.org/2001/XMLSchema#string

Volker Kinzel

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1595-607

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scholarly article

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4974214

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10.1016/J.STR.2003.11.002

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12

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11

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2003-12-01T00:00:00Z

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14656443

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