Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes
about
Three decades of beta-lactamase inhibitorsStructure of AmpC β-lactamase (AmpCD) from anEscherichia coliclinical isolate with a tripeptide deletion (Gly286-Ser287-Asp288) in the H10 helixTwo alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a β-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolaseX-ray Crystallographic Analysis of the 6-Aminohexanoate Cyclic Dimer Hydrolase: CATALYTIC MECHANISM AND EVOLUTION OF AN ENZYME RESPONSIBLE FOR NYLON-6 BYPRODUCT DEGRADATIONStructural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceFragment-guided design of subnanomolar -lactamase inhibitors active in vivoStructure of the extended-spectrum class C β-lactamase ADC-1 fromAcinetobacter baumanniiStructural analysis of the Asn152Gly mutant of P99 cephalosporinaseCrystal Structure of Mox-1, a Unique Plasmid-Mediated Class C -Lactamase with Hydrolytic Activity towards MoxalactamSubstrate Deconstruction and the Nonadditivity of Enzyme RecognitionIncreasing Chemical Space Coverage by Combining Empirical and Computational Fragment ScreensAvibactam and Class C -Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for ResistanceStructural basis for the β-lactamase activity of EstU1, a family VIII carboxylesteraseFlexibility Correlation between Active Site Regions Is Conserved across Four AmpC β-Lactamase EnzymesEnhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase.Hydrolysis spectrum extension of CMY-2-like β-lactamases resulting from structural alteration in the Y-X-N loop.CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmidsKinetic properties of four plasmid-mediated AmpC beta-lactamases.Structural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled β-lactamase.Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation.Mutations affecting the internal equilibrium of the reaction catalyzed by 6-aminohexanoate-dimer hydrolase.Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.
P2860
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P2860
Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Hydrolysis of third-generation ...... and extended spectrum enzymes
@ast
Hydrolysis of third-generation ...... and extended spectrum enzymes
@en
Hydrolysis of third-generation ...... and extended spectrum enzymes
@nl
type
label
Hydrolysis of third-generation ...... and extended spectrum enzymes
@ast
Hydrolysis of third-generation ...... and extended spectrum enzymes
@en
Hydrolysis of third-generation ...... and extended spectrum enzymes
@nl
prefLabel
Hydrolysis of third-generation ...... and extended spectrum enzymes
@ast
Hydrolysis of third-generation ...... and extended spectrum enzymes
@en
Hydrolysis of third-generation ...... and extended spectrum enzymes
@nl
P2093
P2860
P356
P1476
Hydrolysis of third-generation ...... and extended spectrum enzymes
@en
P2093
James R Knox
Kayoko Nukaga
Michiyoshi Nukaga
P2860
P304
P356
10.1074/JBC.M312356200
P407
P50
P577
2003-12-03T00:00:00Z