Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
about
Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulationSelf-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interactionPlk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppressionPLK-1 Targeted Inhibitors and Their Potential against TumorigenesisMolecular dynamics of PLK1 during mitosisStructure of theBrachydanio rerioPolo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzymeFrom Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1Serendipitous alkylation of a Plk1 ligand uncovers a new binding channelIdentification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based DiversificationDbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interactionDynamic and multi-pharmacophore modeling for designing polo-box domain inhibitorsDesign and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance.Polo-box domain: a versatile mediator of polo-like kinase function.Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1.Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis.Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.From Plk1 to Plk5: functional evolution of polo-like kinasesStructure-function relationship of the Polo-like kinase in Trypanosoma brucei.Mechanisms of MAVS regulation at the mitochondrial membrane.Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis.Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes.Current assessment of polo-like kinases as anti-tumor drug targets.Understanding the Polo Kinase machine.Calmodulin activation of polo-like kinase 1 is required during mitotic entry.Targeted delivery of a phosphopeptide prodrug inhibits the proliferation of a human glioma cell line.Playing polo during mitosis: PLK1 takes the lead.Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies.Henipavirus V protein association with Polo-like kinase reveals functional overlap with STAT1 binding and interferon evasion.Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.Functional dynamics of Polo-like kinase 1 at the centrosome.The MORPHEUS protein crystallization screenPolo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.Computational design of targeted inhibitors of polo-like kinase 1 (plk1).A quantitative model of thermal stabilization and destabilization of proteins by ligandsTargeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.
P2860
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P2860
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Molecular and structural basis ...... ns in centrosomal localization
@ast
Molecular and structural basis ...... ns in centrosomal localization
@en
Molecular and structural basis ...... ns in centrosomal localization
@nl
type
label
Molecular and structural basis ...... ns in centrosomal localization
@ast
Molecular and structural basis ...... ns in centrosomal localization
@en
Molecular and structural basis ...... ns in centrosomal localization
@nl
prefLabel
Molecular and structural basis ...... ns in centrosomal localization
@ast
Molecular and structural basis ...... ns in centrosomal localization
@en
Molecular and structural basis ...... ns in centrosomal localization
@nl
P2860
P50
P356
P1476
Molecular and structural basis ...... ns in centrosomal localization
@en
P2093
Elisabeth Bragado-Nilsson
Sonia Ibañez
P2860
P304
P356
10.1073/PNAS.0609131104
P407
P577
2007-02-27T00:00:00Z