Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification - Wikidata - awgldk - TriplyDB

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

http://www.wikidata.org/entity/Q27676966

about

Putting a bit into the polo-box domain of polo-like kinase 1 Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1 Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1 High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay Oxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic species Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1 High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.4R- and 4S-iodophenyl hydroxyproline, 4R-pentynoyl hydroxyproline, and S-propargyl-4-thiolphenylalanine: conformationally biased and tunable amino acids for bioorthogonal reactions.Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization.The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1.Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.The hunt for antimitotic agents: an overview of structure-based design strategies.Development of Bifunctional Inhibitors of Polo-Like Kinase 1 with Low-Nanomolar Activities Against the Polo-Box Domain.Rational Molecular Design of Potent PLK1 PBD Domain-binding Phosphopeptides Using Preferential Amino Acid Building Blocks.Receptor-templated stapling of intrinsically disordered peptide ligands.Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain.Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis.Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.Design, synthesis, and evaluation of non-ATP-competitive small-molecule Polo-like kinase 1 (Plk1) inhibitors.Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function.

P2860

Q26779135-0FD5E439-F1CC-48D9-B871-3B1ED4D15776 Q27672807-74335B66-D7C2-48AC-B069-4D369D29ED83 Q27680590-F2492338-B9C8-4E87-BAD6-51F04B776B46 Q27681364-2833B1E9-3DA5-4F9B-8292-E70E1A329B63 Q27685194-20D1D972-DED6-47E6-B5F2-25937CC7A4FB Q28542938-20CBBCB9-8A41-46E3-930A-FCF6E6A6C637 Q30530234-53F1E1C0-2BE0-4BEB-9423-AECC828069BF Q31039611-90AC1753-F9CA-4AE1-A41E-94A2B71D443B Q33873351-6162C43D-1004-4E8D-A996-A4F2BE6D253A Q34262850-36C50DA4-37DD-4877-9558-1E9590896399 Q34567179-EBFAFA1E-1867-40D8-A73A-61DA980FDF20 Q34663848-40866EAA-D15C-4B92-BEB2-A48BDAE09B11 Q35867866-C26AF7A6-19A0-40D8-A4F2-A5BA888A443E Q36207913-C2B1F688-48AC-45A1-966A-AA187C307486 Q36293407-EFC4885B-8EA0-4A06-A1A7-8517EDBAA017 Q36386336-DB8986FA-1B2C-4B8F-8CA0-888C342D9A59 Q36488706-C53301B9-EE5D-4461-B737-86D99A69F562 Q36976154-3767610B-F4BF-485F-83CA-0C5E23DE78CE Q37239388-16E11755-8FC8-4A2F-BAAC-7E96D12A0111 Q37383729-95A028FA-2650-4842-9099-39918B4B9A27 Q38808120-2E6BCE46-F815-42BC-BF39-DA28AD9AA155 Q40244099-FEFE7293-B020-4C78-8205-96F673968986 Q40602376-0B9141EF-BA49-4BCB-9458-2709E458FBC6 Q41250916-55F6D664-CE83-45DB-8E5E-B1B5B480D3D2 Q42383972-35203342-8F06-4796-8940-82EE95889218 Q43091367-55A2850B-3F43-4DB0-9BAA-1A7158C00B81 Q45068538-1FF511BB-6132-474E-B783-216AF1807D15 Q50994164-DD60B652-2F7B-4730-8D4A-3BF352E49053 Q51101229-93484A9E-5673-43CE-8467-70A8767E3821 Q53000908-08A98A95-26FC-4EBB-AAAF-28072BC53C91 Q54341332-29F78863-F56D-4619-B412-E637172F440C

P2860

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

http://www.wikidata.org/entity/Q27676966

description

2012 nî lūn-bûn

@nan

2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Identification of High Affinit ...... ng Oxime-Based Diversification

@ast

Identification of High Affinit ...... ng Oxime-Based Diversification

@en

Identification of High Affinit ...... ng Oxime-Based Diversification

@nl

type

label

Identification of High Affinit ...... ng Oxime-Based Diversification

@ast

Identification of High Affinit ...... ng Oxime-Based Diversification

@en

Identification of High Affinit ...... ng Oxime-Based Diversification

@nl

prefLabel

Identification of High Affinit ...... ng Oxime-Based Diversification

@ast

Identification of High Affinit ...... ng Oxime-Based Diversification

@en

Identification of High Affinit ...... ng Oxime-Based Diversification

@nl

P1433

Q27676966-EEBF4802-0B23-4F56-A2E6-D242DE753F60

P1476

Q27676966-DCC4DB83-910E-4FB3-8167-74C26ACA42E7

P2093

Q27676966-140C7981-95DB-41EF-85A5-7FE0C52899D0

Q27676966-1E4CB14C-5616-4836-AA24-164FF86BAA51

Q27676966-939DD126-DD69-4602-922E-5CD63444A3C7

Q27676966-9B8DC9DB-A720-40D9-8464-BE9ABE42D16E

Q27676966-9B9CB9EF-D002-4847-B3DB-8A82B2A0B57A

Q27676966-A1A93370-DCD5-4D52-8D1B-C2CA438D503E

Q27676966-C69D5360-5A3D-4109-AAA1-224116BE46DC

Q27676966-DB984AF6-06CB-493D-9E1D-CFBA1622F4C4

Q27676966-E5C20AEF-7BA5-48B3-A5E5-2DA3D6B9A8E6

P2860

Q27676966-074EF69E-9DAA-4E37-92B9-2262ADA41A82

Q27676966-213CAC55-4FE5-4493-AD88-5D580114397A

Q27676966-2581B17F-B773-4673-A713-163DA1505A6B

Q27676966-32BC4E2C-775E-4E13-B36A-3D9BDCA76A2D

Q27676966-37F17C61-D11B-41FD-BDED-CB7B4B64CF40

Q27676966-3A47EC27-6616-420F-917B-7E2D84ADA909

Q27676966-3FA4C7D0-78A7-4B6D-8FBD-84C984291804

Q27676966-49547345-799F-473A-99EC-F024E8758ACF

Q27676966-55357E75-05B7-497B-8A94-E33017B24E53

Q27676966-5FA84CD7-135D-43D1-AE2A-FA8071A14CEA

P304

Q27676966-1B0DD194-267A-4D1F-B0BF-A59873E26828

P31

Q27676966-11BFD01E-CF6A-4048-84B7-FA6F8A207D32

P356

Q27676966-AAB8216F-5362-499A-B119-2CF14F9B80D5

P433

Q27676966-9973EF79-A857-4CD2-BDEB-11CE97243B74

P478

Q27676966-04A35BFC-EF93-467C-89E8-325410DAFAFD

P577

Q27676966-4C7B3516-2880-471E-AEBE-3D65CDA34B16

P5875

Q27676966-D8CF84F7-3372-470C-B50E-2C3E415C84BD

P698

Q27676966-2545B318-1A7B-4F2E-BCF6-119B72BB0225

P932

Q27676966-34F9A61B-CB35-401C-A5FC-077E70B67C13

P356

P1433

ACS Chemical Biology

P1476

Identification of High Affinit ...... ng Oxime-Based Diversification

@en

P2093

Andrej Scharow

http://www.w3.org/2001/XMLSchema#string

Dan Lim

http://www.w3.org/2001/XMLSchema#string

Fa Liu

http://www.w3.org/2001/XMLSchema#string

Jung-Eun Park

http://www.w3.org/2001/XMLSchema#string

Kyung S Lee

http://www.w3.org/2001/XMLSchema#string

Michael B Yaffe

http://www.w3.org/2001/XMLSchema#string

Terrence R Burke

http://www.w3.org/2001/XMLSchema#string

Thorsten Berg

http://www.w3.org/2001/XMLSchema#string

Wen-Jian Qian

http://www.w3.org/2001/XMLSchema#string

P2860

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

Hydrolytic stability of hydrazones and oximes

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

Elucidation of New Binding Interactions with the Human Tsg101 Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

Protected aminooxyprolines for expedited library synthesis: application to Tsg101-directed proline-oxime containing peptides

SAR by oxime-containing peptide libraries: application to Tsg101 ligand optimization.

P304

805-10

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/CB200469A

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P577

2012-05-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221794074

http://www.w3.org/2001/XMLSchema#string

P698

22292814

http://www.w3.org/2001/XMLSchema#string

P932

3355227

http://www.w3.org/2001/XMLSchema#string