Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives
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Structural Insights into Parasite eIF4E Binding Specificity for m7G and m2,2,7G mRNA CapsStructure-Based Mutational Analysis of eIF4E in Relation to sbm1 Resistance to Pea Seed-Borne Mosaic Virus in PeaCrystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repressionStructural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiationStructural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4ERational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfacesDesign of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisationNontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translationDesign, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMPApplications of Phosphate Modification and Labeling to Study (m)RNA Caps.Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism.Distinct features of cap binding by eIF4E1b proteinsDistinct recruitment of human eIF4E isoforms to processing bodies and stress granulesExpression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein.Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.Potential therapeutic applications of RNA cap analogs.The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.Targeting translation: eIF4E as an emerging anticancer drug target.Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation.Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.Comprehensive Identification of RNA-Binding Domains in Human Cells.
P2860
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P2860
Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@ast
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@en
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@nl
type
label
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@ast
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@en
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@nl
prefLabel
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@ast
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@en
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@nl
P50
P3181
P1476
Crystallographic and mass spec ...... h N7-alkylated cap derivatives
@en
P2093
Christopher J Brown
P3181
P356
10.1016/J.JMB.2007.06.033
P407
P577
2007-09-07T00:00:00Z