Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors - Wikidata - awgldk - TriplyDB

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

http://www.wikidata.org/entity/Q27646947

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Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening Comprehensive characterization of the Published Kinase Inhibitor Set Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays Kinetic barriers in the isomerization of substituted ureas: implications for computer-aided drug design Polymer supported synthesis of novel benzoxazole linked benzimidazoles under microwave conditions: in vitro evaluation of VEGFR-3 kinase inhibition activity.Development and strategies of VEGFR-2/KDR inhibitors.Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach.Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.Pyrrolo[3,2-d]pyrimidine derivatives as type II kinase insert domain receptor (KDR) inhibitors: CoMFA and CoMSIA studies.Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase states Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents.Alternative assay formats to identify diverse inhibitors of protein kinases.Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.Structural Determinant and Its Underlying Molecular Mechanism of STPC2 Related to Anti-Angiogenic Activity Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling.Design, Synthesis and Biological Evaluation of Novel Substituted N,N'-Diaryl ureas as Potent p38 Inhibitors.3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.Quinazoline-2,4(1H, 3H)-diones inhibit the growth of multiple human tumor cell lines.New antihyperglycemic, alpha-glucosidase inhibitory, and cytotoxic derivatives of benzimidazoles.Evolution of a New Class of VEGFR-2 Inhibitors from Scaffold Morphing and Redesign.Synthesis, characterization, and biological evaluation of benzimidazole derivatives as potential anxiolytics.Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity.Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry.Discovery of wt RET and V804M RET Inhibitors: From Hit to Lead.Synthesis and cytotoxic evaluation of some novel quinoxalinedione diarylamide sorafenib analogues.DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.LeadOp+R: Structure-Based Lead Optimization With Synthetic Accessibility.Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as the flexible linker.Pharmacophore based 3D-QSAR modeling and free energy analysis of VEGFR-2 inhibitors.PET molecular imaging of angiogenesis with a multiple tyrosine kinase receptor-targeted agent in a rat model of myocardial infarction.In Silico Molecular Docking Analysis of Natural Pyridoacridines as Anticancer Agents

P2860

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P2860

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

http://www.wikidata.org/entity/Q27646947

description

2007 nî lūn-bûn

@nan

2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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type

label

Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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prefLabel

Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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P1433

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Journal of Medicinal Chemistry

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Discovery of novel benzimidazo ...... FR-2 tyrosine kinase receptors

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P2093

Hideyuki Sato

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Ichiro Mori

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James M Veal

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Kazuya Kano

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Liping Wang

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Masaichi Hasegawa

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Megumi Shibahara

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Mui Cheung

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Naohiko Nishigaki

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Rob I West

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4453-4470

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scholarly article

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996968

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10.1021/JM0611051

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18

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50

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Philip A Harris

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2007-08-04T00:00:00Z

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17676829

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