Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
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The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injuryInteraction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase CIloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humansBinding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activityPhosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMPRolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyteSpecific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A geneNovel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment toolTherapeutic potential of PDE modulation in treating heart diseaseThe Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insulaSynthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 InhibitorsThe Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitorsCrystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitorsConformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and SildenafilAn insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studiesKinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 InhibitorsConformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF DomainModulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase ActivityHuman phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progressionCardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitorInhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical StimulationReview: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibitionPDE 7 inhibitors: new potential drugs for the therapy of spinal cord injuryA biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the ratCilostazol Induces PGI2 Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLCε and to Activate p44/42 MAPK in Human Aortic Endothelial CellsDelphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial CellsSpeed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and modelscGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac MyocytesThe Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.Phosphodiesterase 1A modulates cystogenesis in zebrafish.A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway.PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.
P2860
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P2860
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
description
2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@ast
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@de
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@en
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@nl
type
label
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@ast
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@de
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@en
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@nl
prefLabel
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@ast
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@de
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@en
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@nl
P3181
P1476
Cyclic nucleotide phosphodiest ...... of specific therapeutic agents
@en
P2093
Claire Lugnier
P304
P3181
P356
10.1016/J.PHARMTHERA.2005.07.003
P407
P577
2006-03-01T00:00:00Z