Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme
about
Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozymeRiboswitch effectors as protein enzyme cofactorsMechanism of mRNA destabilization by the glmS ribozymeThe roles of metal ions in regulation by riboswitchesThermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitchAn in vitro evolved glmS ribozyme has the wild-type fold but loses coenzyme dependenceValidating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch SpecificallyMetabolite recognition principles and molecular mechanisms underlying riboswitch functionThe glmS ribozyme cofactor is a general acid-base catalystThe glmS ribozyme: use of a small molecule coenzyme by a gene-regulatory RNAUse of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small moleculesSmall self-cleaving ribozymesNew molecular engineering approaches for crystallographic studies of large RNAsDramatic improvement of crystals of large RNAs by cation replacement and dehydrationUse of the spliceosomal protein U1A to facilitate crystallization and structure determination of complex RNAsDeciphering the role of glucosamine-6-phosphate in the riboswitch action of glmS ribozymePhosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch.Crystallographic analysis of TPP riboswitch binding by small-molecule ligands discovered through fragment-based drug discovery approachesThe structural and functional diversity of metabolite-binding riboswitchesRole of the active site guanine in the glmS ribozyme self-cleavage mechanism: quantum mechanical/molecular mechanical free energy simulationsThe glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphateRiboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme bindingGlucosamine and glucosamine-6-phosphate derivatives: catalytic cofactor analogues for the glmS ribozymeRibozymes and riboswitches: modulation of RNA function by small molecules.Riboswitch-based antibacterial drug discovery using high-throughput screening methods.In vitro evolution of coenzyme-independent variants from the glmS ribozyme structural scaffold.An active-site guanine participates in glmS ribozyme catalysis in its protonated stateChemical feasibility of the general acid/base mechanism of glmS ribozyme self-cleavage.Assessing the Potential Effects of Active Site Mg2+ Ions in the glmS Ribozyme-Cofactor ComplexProtonation states of the key active site residues and structural dynamics of the glmS riboswitch as revealed by molecular dynamics.Mechanism and distribution of glmS ribozymes.The glmS riboswitch integrates signals from activating and inhibitory metabolites in vivo.Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements.glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality.RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.Ligand design for riboswitches, an emerging target class for novel antibiotics.Fluoro-Carba-Sugars are Glycomimetic Activators of the glmS Ribozyme.The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme.A divalent cation-dependent variant of the glmS ribozyme with stringent Ca2+ selectivity co-opts a preexisting nonspecific metal ion-binding site.
P2860
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P2860
Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@ast
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@en
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@nl
type
label
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@ast
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@en
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@nl
prefLabel
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@ast
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@en
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@nl
P2093
P2860
P1476
Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme
@en
P2093
Adrian R Ferré-D'Amaré
Daniel J Klein
Michael D Been
Sara R Wilkinson
P2860
P304
P356
10.1016/J.JMB.2007.07.062
P407
P577
2007-10-12T00:00:00Z