Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme - Wikidata - awgldk - TriplyDB

Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme

Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme

http://www.wikidata.org/entity/Q27647856

about

Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme Riboswitch effectors as protein enzyme cofactors Mechanism of mRNA destabilization by the glmS ribozyme The roles of metal ions in regulation by riboswitches Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch An in vitro evolved glmS ribozyme has the wild-type fold but loses coenzyme dependence Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically Metabolite recognition principles and molecular mechanisms underlying riboswitch function The glmS ribozyme cofactor is a general acid-base catalyst The glmS ribozyme: use of a small molecule coenzyme by a gene-regulatory RNA Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules Small self-cleaving ribozymes New molecular engineering approaches for crystallographic studies of large RNAs Dramatic improvement of crystals of large RNAs by cation replacement and dehydration Use of the spliceosomal protein U1A to facilitate crystallization and structure determination of complex RNAs Deciphering the role of glucosamine-6-phosphate in the riboswitch action of glmS ribozyme Phosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch.Crystallographic analysis of TPP riboswitch binding by small-molecule ligands discovered through fragment-based drug discovery approaches The structural and functional diversity of metabolite-binding riboswitches Role of the active site guanine in the glmS ribozyme self-cleavage mechanism: quantum mechanical/molecular mechanical free energy simulations The glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphate Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme binding Glucosamine and glucosamine-6-phosphate derivatives: catalytic cofactor analogues for the glmS ribozyme Ribozymes and riboswitches: modulation of RNA function by small molecules.Riboswitch-based antibacterial drug discovery using high-throughput screening methods.In vitro evolution of coenzyme-independent variants from the glmS ribozyme structural scaffold.An active-site guanine participates in glmS ribozyme catalysis in its protonated state Chemical feasibility of the general acid/base mechanism of glmS ribozyme self-cleavage.Assessing the Potential Effects of Active Site Mg2+ Ions in the glmS Ribozyme-Cofactor Complex Protonation states of the key active site residues and structural dynamics of the glmS riboswitch as revealed by molecular dynamics.Mechanism and distribution of glmS ribozymes.The glmS riboswitch integrates signals from activating and inhibitory metabolites in vivo.Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements.glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality.RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.Ligand design for riboswitches, an emerging target class for novel antibiotics.Fluoro-Carba-Sugars are Glycomimetic Activators of the glmS Ribozyme.The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme.A divalent cation-dependent variant of the glmS ribozyme with stringent Ca2+ selectivity co-opts a preexisting nonspecific metal ion-binding site.

P2860

Q24594199-BA2182D4-57F5-4636-A655-9BC5D56E2890 Q24652676-FD6F03EE-FFE9-4447-BB0B-0DB127640653 Q24680823-93807C9F-6C1C-4D96-B6DA-649BDFA797C9 Q26860290-186B5DD2-39DF-41A5-B9B7-7D996E0383CA Q27658383-7C8CB424-5891-4ED5-AE2B-372D81A6A4A3 Q27680143-A589FFC6-26CC-4627-8652-C699DD130F3C Q27683543-C6F627BD-0B46-4793-8BB1-BD3DAA0B0B8F Q28109611-784D6302-33AC-43E7-BD37-8FF39E8E0B91 Q28278331-32CFE0B9-A48C-4D73-B549-C3C79C34FCD8 Q28728642-ECBF97A4-89E2-4238-9333-D454DB71A3D0 Q28741207-510B278B-FE67-4C6F-BEC1-744415097C62 Q28749189-9725A902-C561-42CC-9F59-8BC77DD302CE Q34021859-FAF621DC-4B3A-44F2-B8FF-72D6B75E1CEB Q34257197-8771DF1F-6CCE-422E-B428-6BE70D25ED14 Q34283867-B40E833D-1B89-493D-BC07-F44489760F51 Q34370143-F28E0D3A-CC41-4BAC-8044-924BD33CDE63 Q34756866-07711BF2-6588-4D28-9522-C55B25AB4728 Q34763150-723A4802-449C-49B0-8F83-6FEF5A5C051D Q34965135-6715197C-4051-4073-AA83-6B24CE423BED Q35020704-346A0374-A236-4881-970B-BA1CF185568A Q35217480-D8EBB11A-6FA1-4139-B40E-6DD74865940E Q35350419-7F372339-B89F-47C1-A33E-658754222DFE Q35650668-2C74EF78-6284-4977-B0AA-8F9D5242A6DE Q37057446-9E7FB59C-461A-429A-BCEA-B7CCBE4B6D15 Q37798793-DE77AAA2-AB59-4D7F-8C83-86D4375EBA48 Q38060778-B3F17D43-A7C0-4B22-9796-51B21E10F879 Q38821539-397435CD-5B90-4F2B-B08B-A703547D3DF1 Q39016303-3BA68263-221B-4EE2-A2AA-0165163A1756 Q41095160-E864BA44-A169-4607-9EAC-3DCB7E54BD27 Q41675293-655C6BB2-A0B0-4FD5-A849-FC8E37FDBD65 Q41809931-3772827C-993D-4977-B950-72275C7B826A Q42320789-8E993D0B-EAA3-4DE4-8F67-14C6A6925CB4 Q42705763-F40556D4-5D85-4D4C-9189-030324F373B7 Q42726378-8226EFB4-9DFD-45B2-B0C8-87EB75A357B2 Q42869072-CB737066-027C-43A5-9E9D-306EC86DBF55 Q47235409-4B5EA307-5527-495A-8F34-FB20CE51A680 Q47941828-5E9C96CB-6A46-4771-8981-7486695A04C2 Q48202020-DB63AC0E-F68D-4F35-9BAD-394538AC2E98 Q51139880-90D6291C-A721-44C8-AC38-CA2912143CA7 Q51278089-87D7AC3A-8E6F-4C97-8789-EA3C3BDB198B

P2860

Requirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS Ribozyme

http://www.wikidata.org/entity/Q27647856

description

2007 nî lūn-bûn

@nan

2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@ast

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@en

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@nl

type

label

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@ast

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@en

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@nl

prefLabel

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@ast

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@en

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@nl

P1433

Q27647856-372B5AA5-32F5-47BC-83B8-D02A73C58AB7

P1476

Q27647856-1D212A50-CC87-4B34-A324-EE2C1CA46299

P2093

Q27647856-0D301A6D-B69B-480C-ACEC-ABB438558C01

Q27647856-10389B11-2036-4AF5-89A9-BAD167C87C4B

Q27647856-CE395DEC-87B8-41AB-8B32-7359EBFC09C3

Q27647856-E019767A-1030-4859-A724-40D5B43AD906

P2860

Q27647856-050CE3E0-7BED-4D58-9AEB-D6A166B3C784

Q27647856-054B915C-8C6C-4EB5-8173-833923AED88E

Q27647856-173E57A3-1E7E-4D76-98D1-8F6896FA82AB

Q27647856-1AF98946-EFF2-4F6F-9747-83F44A75297C

Q27647856-228B8F7C-A2DF-4A0A-A1AC-BF9CD3A38925

Q27647856-253952F4-F757-4C0F-809F-0078FED435BA

Q27647856-3D0AFEA0-3862-4235-83B9-42AB45F2DED7

Q27647856-4CBFA786-5213-4826-A830-B3800E7D87FC

Q27647856-54F591B9-744B-47C4-AB55-43765591DBEF

Q27647856-6140049E-17B7-49EC-A8D0-86F8D7AED22E

P304

Q27647856-438C3641-1716-460C-8ED9-646F89109BE9

P31

Q27647856-46E68E03-63AB-495A-9C23-1328CF31C1B2

P356

Q27647856-30790220-383F-422C-92AD-D85D97A8B2C8

P407

Q27647856-4655F314-2E8B-4D37-A4A8-73E279F577F8

P433

Q27647856-C0D00B48-1CEF-4801-936D-BB9680A0D8D6

P478

Q27647856-2AAB025C-8EFD-4C24-B4E4-7341E4E4D502

P577

Q27647856-797ACBFF-B904-411B-ACEB-DCCAC2AE495B

P5875

Q27647856-74F16E5F-D974-4167-BC46-8DCECD9DA56F

P698

Q27647856-6E116CC9-6963-4EE8-9818-D84F215543C1

P921

Q27647856-2737E82E-853C-4F06-8C0A-153F6354EE19

P932

Q27647856-18A76C53-EC32-4B7B-81A2-79283F025194

P356

J.JMB.2007.07.062

P1433

Journal of Molecular Biology

P1476

Requirement of Helix P2.2 and ...... Cofactor of the glmS Ribozyme

@en

P2093

Adrian R Ferré-D'Amaré

http://www.w3.org/2001/XMLSchema#string

Daniel J Klein

http://www.w3.org/2001/XMLSchema#string

Michael D Been

http://www.w3.org/2001/XMLSchema#string

Sara R Wilkinson

http://www.w3.org/2001/XMLSchema#string

P2860

New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control

RNA tertiary interactions in the large ribosomal subunit: the A-minor motif

Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor

Core requirements for glmS ribozyme self-cleavage reveal a putative pseudoknot structure

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Crystal structure of a hepatitis delta virus ribozyme

Rapid and efficient site-specific mutagenesis without phenotypic selection

Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme

Evidence for preorganization of the glmS ribozyme ligand binding pocket

Control of gene expression by a natural metabolite-responsive ribozyme

P304

178-89

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.JMB.2007.07.062

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

373

http://www.w3.org/2001/XMLSchema#string

P577

2007-10-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6036481

http://www.w3.org/2001/XMLSchema#string

P698

17804015

http://www.w3.org/2001/XMLSchema#string

P921

P932

2048488

http://www.w3.org/2001/XMLSchema#string