Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist
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Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMRHigh-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding siteStructure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 Å resolutionNMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin α1β1NMR structure of bitistatin – a missing piece in the evolutionary pathway of snake venom disintegrinsStructure of a conformationally constrained Arg-Gly-Asp sequence inserted into human lysozymeMetalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction SitesThe solution structure of the N-terminal domain of human vitronectin: proximal sites that regulate fibrinolysis and cell migrationEvaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesionPositional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin alphaIIbbeta3Structure and expression of GSL1 and GSL2 genes encoding gibberellin stimulated-like proteins in diploid and highly heterozygous tetraploid potato reveals their highly conserved and essential statusPrimary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signalingA role for the disintegrin domain of cyritestin, a sperm surface protein belonging to the ADAM family, in mouse sperm-egg plasma membrane adhesion and fusion.The disulfide bond pattern of catrocollastatin C, a disintegrin-like/cysteine-rich protein isolated from Crotalus atrox venom.Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.Savignygrin, a platelet aggregation inhibitor from the soft tick Ornithodoros savignyi, presents the RGD integrin recognition motif on the Kunitz-BPTI fold.Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin alpha5beta1 antagonist from Eristocophis macmahoni venom.Analysis of the role of egg integrins in sperm-egg binding and fusion.Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin alphaIIB beta3.RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor but can be bypassed by an antibody-dependent enhancement pathwayThe precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.The disulphide bond pattern of bitistatin, a disintegrin isolated from the venom of the viper Bitis arietans.ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans.Structure and function of snake venom proteins affecting platelet plug formation.ADAM-15 disintegrin-like domain structure and function.Recombinant decorsin: dynamics of the RGD recognition site.Snake venom toxins: toxicity and medicinal applications.Structure of adenovirus complexed with its internalization receptor, alphavbeta5 integrin.ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.Protein dynamics.Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif.Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.Construction of a divalent cell adhesive lysozyme by introducing the Arg-Gly-Asp sequence at two sites.The exchange of Arg-Gly-Asp (RGD) and Arg-Tyr-Asp (RYD) binding sequences in a recombinant murine Fab fragment specific for the integrin alpha IIb beta 3 does not alter integrin recognition.Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (western diamondback rattlesnake) which inhibits platelet adhesion to collagen.Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.Amino acid sequence and molecular modelling of glycoprotein IIb-IIIa and fibronectin receptor iso-antagonists from Trimeresurus elegans venomThe integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flankiAn echistatin C-terminal peptide activates GPIIbIIIa binding to fibrinogen, fibronectin, vitronectin and collagen type I and type IV.
P2860
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P2860
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist
description
1991 nî lūn-bûn
@nan
1991 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@ast
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@en
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@nl
type
label
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@ast
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@en
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@nl
prefLabel
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@ast
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@en
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@nl
P2093
P3181
P356
P1433
P1476
Solution structure of kistrin, ...... tor and GP IIb-IIIa antagonist
@en
P2093
P3181
P356
10.1126/SCIENCE.1862345
P407
P577
1991-07-26T00:00:00Z