The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanki
about
Applications of snake venom components to modulate integrin activities in cell-matrix interactionsPositional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin alphaIIbbeta3Application of Recombinant Rhodostomin in Studying Cell Adhesion.Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion.Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.Modulation of RGD sequence motifs regulates disintegrin recognition of alphaIIb beta3 and alpha5 beta1 integrin complexes. Replacement of elegantin alanine-50 with proline, N-terminal to the RGD sequence, diminishes recognition of the alpha5 beta1 cDifferential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allosteryImmunological characterization of eristostatin and echistatin binding sites on alpha IIb beta 3 and alpha V beta 3 integrins.The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom.Solution structure of gamma-bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding.Identification of a novel mutation in a non-Jewish factor XI deficient kindred.The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity
P2860
Q27011302-C26F4C03-5005-41E7-BD60-ADFB28341EE7Q28367196-3E856DB2-B22D-4E63-87F4-5A62E16030A7Q34974087-2A7A2F99-2D27-4913-88DD-2D9ED7E1F2DFQ39933322-9D086D8D-5FED-4F31-82D6-73006C9FCACDQ40864152-F69C33D8-B29B-434E-B1A8-819C6FB8AEE5Q41769202-5393587D-0C29-42FF-B43E-7EA2CEFACE61Q41778652-F0E4F6D8-F739-440F-A1E0-F6D9E0A8B86CQ42249278-9B7E4ACB-0A09-4181-A785-A2F61ACC28BDQ43742778-1BC0474E-01C4-4328-AFEE-6C296E5545FAQ45076939-EB8354BD-CFA4-435A-A579-5A88584C9A96Q45856540-DF1844BB-41B9-44C9-B24F-E7554E937A88Q51803883-2CB4B2C1-829C-4743-85FF-3E35DD1EAFECQ58058093-DDB54A13-5C4A-4569-8337-7DD83F262CD8
P2860
The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanki
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The integrin alpha IIb beta 3 ...... amino acid environment flanki
@en
type
label
The integrin alpha IIb beta 3 ...... amino acid environment flanki
@en
prefLabel
The integrin alpha IIb beta 3 ...... amino acid environment flanki
@en
P2093
P2860
P356
P1433
P1476
The integrin alpha IIb beta 3 ...... amino acid environment flanki
@en
P2093
P2860
P304
P356
10.1042/BJ3120223
P407
P478
312 ( Pt 1)
P577
1995-11-01T00:00:00Z