Discovery of a potent and selective aurora kinase inhibitor - Wikidata - awgldk - TriplyDB

Discovery of a potent and selective aurora kinase inhibitor

Discovery of a potent and selective aurora kinase inhibitor

http://www.wikidata.org/entity/Q27651407

about

Maintaining Genome Stability in Defiance of Mitotic DNA Damage Functions of Aurora kinase C in meiosis and cancer Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.A sensitive and selective liquid chromatography/tandem mass spectrometry method for determination of MLN8237 in human plasma.3D-QSAR and molecular docking studies on derivatives of MK-0457, GSK1070916 and SNS-314 as inhibitors against Aurora B kinase.Significance estimation for sequence-based chemical similarity searching (PhAST) and application to AuroraA kinase inhibitors.Update on aurora kinase inhibitors in gynecologic malignancies.Advances in fragment-based drug discovery platforms.Update on Aurora Kinase Targeted Therapeutics in Oncology.Aurora kinases as druggable targets in pediatric leukemia: heterogeneity in target modulation activities and cytotoxicity by diverse novel therapeutic agents.A molecular mechanics approach to modeling protein-ligand interactions: relative binding affinities in congeneric series.Identification of signalling cascades involved in red blood cell shrinkage and vesiculation.Aurora kinase inhibitors as anticancer molecules.The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing.Advances in Aurora kinase inhibitor patents.Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Aurora kinase inhibitors: progress towards the clinic ENMD-2076 for hematological malignancies.The Aurora kinase inhibitors in cancer research and therapy.Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.Rationalizing tight ligand binding through cooperative interaction networks.Classification of Aurora-A Kinase Inhibitors Using Self-Organizing Map (SOM) and Support Vector Machine (SVM).A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.Identification of new novel scaffold for Aurora A inhibition by pharmacophore modeling and virtual screening.Application of shape-based and pharmacophore-based in silico screens for identification of Type II protein kinase inhibitors.

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Discovery of a potent and selective aurora kinase inhibitor

http://www.wikidata.org/entity/Q27651407

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Discovery of a potent and selective aurora kinase inhibitor

@ast

Discovery of a potent and selective aurora kinase inhibitor

@en

Discovery of a potent and selective aurora kinase inhibitor

@nl

type

label

Discovery of a potent and selective aurora kinase inhibitor

@ast

Discovery of a potent and selective aurora kinase inhibitor

@en

Discovery of a potent and selective aurora kinase inhibitor

@nl

prefLabel

Discovery of a potent and selective aurora kinase inhibitor

@ast

Discovery of a potent and selective aurora kinase inhibitor

@en

Discovery of a potent and selective aurora kinase inhibitor

@nl

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P356

J.BMCL.2008.07.073

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Bioorganic & Medicinal Chemistry Letters

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Discovery of a potent and selective aurora kinase inhibitor

@en

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Amy D Fung

http://www.w3.org/2001/XMLSchema#string

Bradley T Tangonan

http://www.w3.org/2001/XMLSchema#string

Chris E Lawrence

http://www.w3.org/2001/XMLSchema#string

Chul H Yu

http://www.w3.org/2001/XMLSchema#string

Darin A Allen

http://www.w3.org/2001/XMLSchema#string

Emily J Hanan

http://www.w3.org/2001/XMLSchema#string

Jeffrey A Silverman

http://www.w3.org/2001/XMLSchema#string

Jeffrey W Jacobs

http://www.w3.org/2001/XMLSchema#string

Johan D Oslob

http://www.w3.org/2001/XMLSchema#string

Joni Lam

http://www.w3.org/2001/XMLSchema#string

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4880-4884

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scholarly article

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4453857

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10.1016/J.BMCL.2008.07.073

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17

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18

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2008-07-24T00:00:00Z

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18678489

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