The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing.
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Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewKinases as druggable targets in trypanosomatid protozoan parasitesDrug repurposing and human parasitic protozoan diseasesRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisIdentification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaignNew chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugsEVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA.Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.In vitro screening for drug repositioning.Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery.Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?Repurposing strategies for tropical disease drug discovery.Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasisEnzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity using Modern Machine Learning Algorithms.Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation
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P2860
The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
The human Aurora kinase inhibi ...... covery via target repurposing.
@ast
The human Aurora kinase inhibi ...... covery via target repurposing.
@en
type
label
The human Aurora kinase inhibi ...... covery via target repurposing.
@ast
The human Aurora kinase inhibi ...... covery via target repurposing.
@en
prefLabel
The human Aurora kinase inhibi ...... covery via target repurposing.
@ast
The human Aurora kinase inhibi ...... covery via target repurposing.
@en
P2093
P2860
P1476
The human Aurora kinase inhibi ...... scovery via target repurposing
@en
P2093
Larry Ruben
Rishika Kapoor
Stefan O Ochiana
Vidya Pandarinath
Zhouxi Wang
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P304
P356
10.1016/J.EJMECH.2012.07.038
P577
2012-07-31T00:00:00Z