Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

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http://www.wikidata.org/entity/Q27652985
FAK in cancer: mechanistic findings and clinical applicationsNovel mutant-selective EGFR kinase inhibitors against EGFR T790MCrystal structure of the ALK (anaplastic lymphoma kinase) catalytic domainDevelopment of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsThe R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma KinaseTAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer CellsTargeting Pyk2 for therapeutic interventionAllosteric regulation of focal adhesion kinase by PIP₂ and ATP.How focal adhesion kinase achieves regulation by linking ligand binding, localization and actionEndothelial FAK as a therapeutic target in disease.Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.Multiple steps to activate FAK's kinase domain: adaptation to confined environments?Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review.Exploring the interaction between human focal adhesion kinase and inhibitors: a molecular dynamic simulation and free energy calculations.Epistructural Drug Design to Treat Cancer Metastasis and the Associated Drug ResistanceTargeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions
P2860

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Item
http://www.wikidata.org/entity/Q27652985
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2008 nî lūn-bûn
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2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
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2008年の論文
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2008年論文
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2008年論文
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2008年論文
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2008年論文
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2008年論文
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2008年论文
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name
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
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Crystal Structures of the FAK ...... eal a Helical DFG Conformation
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Crystal Structures of the FAK ...... eal a Helical DFG Conformation
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type
label
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
@ast
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
@en
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
@nl
prefLabel
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
@ast
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
@en
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
@nl
P1433
P1476
P2093
P2860
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P5875
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P1476
Crystal Structures of the FAK ...... eal a Helical DFG Conformation
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P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0003800
P407
P433
P478
P50
P577
P5875
P698
P921
P932